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Proteins/UNIPROT:A8K855

EFCAB7

Protein·UNIPROT:A8K855

Open in the graph

Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia..

Function from UniProtKB (A8K855), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

polydactyly has a germline basis in EFCAB7DiseaseGenCC HGNC:29379|MONDO:0021003Inferred only

Statements

13 statements

13 statements · 4 reference databases · Subject: EFCAB7 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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IFNL2 covaries with EFCAB7ProteinHetionet hetionet:covaries:282616-84455Inferred only
MS4A7 covaries with EFCAB7ProteinHetionet hetionet:covaries:58475-84455Inferred only
PBLD covaries with EFCAB7ProteinHetionet hetionet:covaries:64081-84455Inferred only
TMEM231 covaries with EFCAB7ProteinHetionet hetionet:covaries:79583-84455Inferred only
EFCAB7 participates in Activation of SMOPathwayReactome R-HSA-5635838Inferred only
EFCAB7 participates in Genes related to primary cilium development based on CRISPR PathwayWikiPathways WP4536Inferred only
EFCAB7 participates in Hedgehog 'on' statePathwayReactome R-HSA-5632684Inferred only
EFCAB7 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
EFCAB7 participates in Signaling by HedgehogPathwayReactome R-HSA-5358351Inferred only
EFCAB7 regulates positive regulation of protein import into nucleusBiological processgene ontology A8K855|GO:0042307Inferred only
EFCAB7 regulates positive regulation of protein localization to ciliary membraneBiological processgene ontology A8K855|GO:1903569Inferred only
EFCAB7 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology A8K855|GO:0045944Inferred only

Show the remaining 1

EFCAB7 regulates regulation of smoothened signaling pathwayBiological processgene ontology A8K855|GO:0008589Inferred only

Other names

2 names

Resolves to: EFCAB7

Also called: EF-hand calcium-binding domain-containing protein 7KIAA1799

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