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Proteins/UNIPROT:Q9UBV2

SEL1L

Protein·UNIPROT:Q9UBV2

Open in the graph

Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling..

Function from UniProtKB (Q9UBV2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

neurodevelopmental disorder has a germline basis in SEL1LDiseaseGenCC HGNC:10717|MONDO:0700092Inferred only

Statements

42 statements

42 statements · 3 reference databases · Subject: SEL1L · Sources: Hetionet, Reactome, WikiPathways

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SEL1L interacts with EDEM1ProteinHetionet hetionet:interacts:6400-9695Inferred only
SEL1L interacts with FOXRED2ProteinHetionet hetionet:interacts:6400-80020Inferred only
SEL1L interacts with OS9ProteinHetionet hetionet:interacts:10956-6400Inferred only
RPL6 interacts with SEL1LProteinHetionet hetionet:interacts:6128-6400Inferred only
SEL1L interacts with SYVN1ProteinHetionet hetionet:interacts:6400-84447Inferred only
SEL1L interacts with UBCProteinHetionet hetionet:interacts:6400-7316Inferred only
SEL1L participates in ABC transporter disordersPathwayReactome R-HSA-5619084Inferred only
SEL1L participates in ABC-family protein mediated transportPathwayReactome R-HSA-382556Inferred only
SEL1L participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
SEL1L participates in AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)PathwayReactome R-HSA-9931269Inferred only
SEL1L participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
SEL1L participates in Calnexin/calreticulin cyclePathwayReactome R-HSA-901042Inferred only

Show the remaining 30

SEL1L participates in Co-inhibition by PD-1PathwayReactome R-HSA-389948Inferred only
SEL1L participates in Defective CFTR causes cystic fibrosisPathwayReactome R-HSA-5678895Inferred only
SEL1L participates in DiseasePathwayReactome R-HSA-1643685Inferred only
SEL1L participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
SEL1L participates in Disorders of transmembrane transportersPathwayReactome R-HSA-5619115Inferred only
SEL1L participates in ER Quality Control Compartment (ERQC)PathwayReactome R-HSA-901032Inferred only
SEL1L participates in Familial hyperlipidemia type 1PathwayWikiPathways WP5108Inferred only
SEL1L participates in Familial hyperlipidemia type 4PathwayWikiPathways WP5111Inferred only
SEL1L participates in Familial hyperlipidemia type 5PathwayWikiPathways WP5112Inferred only
SEL1L participates in Hedgehog ligand biogenesisPathwayReactome R-HSA-5358346Inferred only
SEL1L participates in Hh mutants abrogate ligand secretionPathwayReactome R-HSA-5387390Inferred only
SEL1L participates in Hh mutants are degraded by ERADPathwayReactome R-HSA-5362768Inferred only
SEL1L participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
SEL1L participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
SEL1L participates in N-glycan trimming in the ER and Calnexin/Calreticulin cyclePathwayReactome R-HSA-532668Inferred only
SEL1L participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
SEL1L participates in Pre-NOTCH Expression and ProcessingPathwayReactome R-HSA-1912422Inferred only
SEL1L participates in Pre-NOTCH Processing in GolgiPathwayReactome R-HSA-1912420Inferred only
SEL1L participates in Regulation of PD-L1(CD274) expressionPathwayReactome R-HSA-9909648Inferred only
SEL1L participates in Regulation of PD-L1(CD274) Post-translational modificationPathwayReactome R-HSA-9909615Inferred only
SEL1L participates in Regulation of T cell activation by CD28 familyPathwayReactome R-HSA-388841Inferred only
SEL1L participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
SEL1L participates in Signaling by HedgehogPathwayReactome R-HSA-5358351Inferred only
SEL1L participates in Signaling by NOTCHPathwayReactome R-HSA-157118Inferred only
SEL1L participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
C1QA increases the expression of SEL1LProteinHetionet hetionet:regulates:712-6400Inferred only
EBF1 increases the expression of SEL1LProteinHetionet hetionet:regulates:1879-6400Inferred only
HSPA5 increases the expression of SEL1LProteinHetionet hetionet:regulates:3309-6400Inferred only
RTN4RL1 increases the expression of SEL1LProteinHetionet hetionet:regulates:146760-6400Inferred only
SLC4A2 increases the expression of SEL1LProteinHetionet hetionet:regulates:6522-6400Inferred only

Other names

3 names

Resolves to: SEL1L

Also called: Sel-1LSuppressor of lin-12-like protein 1TSA305

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