Proteins/UNIPROT:O95995

DRC4

ProteinUNIPROT:O95995

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (By similarity)..

Function from UniProtKB (O95995), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

primary ciliary dyskinesia has a germline basis in DRC4DiseaseGenCC HGNC:4166|MONDO:0016575Inferred only
primary ciliary dyskinesia 33 has a germline basis in DRC4DiseaseGenCC HGNC:4166|MONDO:0014750Inferred only

Statements

11 statements

11 statements · 4 reference databases · Subject: DRC4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

DRC4 interacts with CIAO1ProteinHetionet hetionet:interacts:2622-9391Inferred only
DRC4 interacts with IQCB1ProteinHetionet hetionet:interacts:2622-9657Inferred only
DRC4 participates in Activation of SMOPathwayReactome R-HSA-5635838Inferred only
DRC4 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
DRC4 participates in Hedgehog 'on' statePathwayReactome R-HSA-5632684Inferred only
DRC4 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
DRC4 participates in Signaling by HedgehogPathwayReactome R-HSA-5358351Inferred only
DRC4 participates in Smith Magenis and Potocki Lupski syndrome copy number variationPathwayWikiPathways WP5381Inferred only
DRC4 regulates negative regulation of cell population proliferationBiological processgene ontology O95995|GO:0008285Inferred only
DRC4 regulates positive regulation of protein localization to ciliumBiological processgene ontology O95995|GO:1903566Inferred only
DRC4 regulates positive regulation of smoothened signaling pathwayBiological processgene ontology O95995|GO:0045880Inferred only

Other names

6 names

Resolves to: DRC4

Also called: GAS-11GAS-8GAS11GAS8Growth arrest-specific protein 11Growth arrest-specific protein 8

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