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Proteins/UNIPROT:Q6P988
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors..
Function from UniProtKB (Q6P988), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
24 statements
24 statements · 5 reference databases · Subject: NOTUM · Sources: gene ontology, Hetionet, Reactome, Rhea, WikiPathways
1 reaction
[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine+water[Wnt protein]-L-serine+(9Z)-hexadecenoate+hydron
Catalysed by NOTUM
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:45340CC BY 4.0Reference data
1 name
Resolves to: NOTUM