Proteins/UNIPROT:Q86UK5

EVC2

ProteinUNIPROT:Q86UK5

Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis..

Function from UniProtKB (Q86UK5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

acrofacial dysostosis, Weyers type has a germline basis in EVC2DiseaseGenCC HGNC:19747|MONDO:0008673Inferred only
Ellis-van Creveld syndrome has a germline basis in EVC2DiseaseGenCC HGNC:19747|MONDO:0009162Inferred only

Statements

9 statements

9 statements · 3 reference databases · Subject: EVC2 · Sources: Hetionet, Reactome, WikiPathways

Order

SMAD9 interacts with EVC2ProteinHetionet hetionet:interacts:132884-4093Inferred only
EVC2 participates in Activation of SMOPathwayReactome R-HSA-5635838Inferred only
EVC2 participates in Bardet Biedl syndromePathwayWikiPathways WP5234Inferred only
EVC2 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
EVC2 participates in Genes related to primary cilium development based on CRISPR PathwayWikiPathways WP4536Inferred only
EVC2 participates in Hedgehog 'on' statePathwayReactome R-HSA-5632684Inferred only
EVC2 participates in Hedgehog signalingPathwayWikiPathways WP4249Inferred only
EVC2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
EVC2 participates in Signaling by HedgehogPathwayReactome R-HSA-5358351Inferred only

Other names

2 names

Resolves to: EVC2

Also called: Ellis-van Creveld syndrome protein 2LBN

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