Proteins/UNIPROT:Q7Z4L5

TTC21B

ProteinUNIPROT:Q7Z4L5

Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs. Negatively modulates the SHH signal transduction (By similarity)..

Function from UniProtKB (Q7Z4L5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

asphyxiating thoracic dystrophy 4 has a germline basis in TTC21BDiseaseGenCC HGNC:25660|MONDO:0013441Inferred only
Jeune syndrome has a germline basis in TTC21BDiseaseGenCC HGNC:25660|MONDO:0018770Inferred only
nephronophthisis 12 has a germline basis in TTC21BDiseaseGenCC HGNC:25660|MONDO:0013442Inferred only
nephronophthisis 2 has a germline basis in TTC21BDiseaseGenCC HGNC:25660|MONDO:0011190Inferred only

Statements

16 statements

16 statements · 4 reference databases · Subject: TTC21B · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

TTC21B covaries with LRRIQ1ProteinHetionet hetionet:covaries:79809-84125Inferred only
UBC interacts with TTC21BProteinHetionet hetionet:interacts:7316-79809Inferred only
UBD interacts with TTC21BProteinHetionet hetionet:interacts:10537-79809Inferred only
TTC21B participates in Assembly of the 9+0 primary ciliumPathwayReactome R-HSA-9975921Inferred only
TTC21B participates in Bardet Biedl syndromePathwayWikiPathways WP5234Inferred only
TTC21B participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
TTC21B participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
TTC21B participates in Genes related to primary cilium development based on CRISPR PathwayWikiPathways WP4536Inferred only
TTC21B participates in Hedgehog 'off' statePathwayReactome R-HSA-5610787Inferred only
TTC21B participates in Intraflagellar transportPathwayReactome R-HSA-5620924Inferred only
TTC21B participates in Nephrotic syndromePathwayWikiPathways WP4758Inferred only
TTC21B participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only

Show the remaining 4

TTC21B participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
TTC21B participates in Signaling by HedgehogPathwayReactome R-HSA-5358351Inferred only
TTC21B regulates regulation of intraciliary retrograde transportBiological processgene ontology Q7Z4L5|GO:1905799Inferred only
TTC21B regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q7Z4L5|GO:0006357Inferred only

Other names

4 names

Resolves to: TTC21B

Also called: IFT139Intraflagellar transport 139 homologKIAA1992TPR repeat protein 21B

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