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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q96DZ1

ERLEC1

Protein·UNIPROT:Q96DZ1

Open in the graph

Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins..

Function from UniProtKB (Q96DZ1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

autosomal dominant prognathism has a germline basis in ERLEC1DiseaseGenCC HGNC:25222|MONDO:0008312Inferred only

Statements

34 statements

34 statements · 4 reference databases · Subject: ERLEC1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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ERAP2 covaries with ERLEC1ProteinHetionet hetionet:covaries:27248-64167Inferred only
FAM120C covaries with ERLEC1ProteinHetionet hetionet:covaries:27248-54954Inferred only
ERLEC1 covaries with FKBP8ProteinHetionet hetionet:covaries:23770-27248Inferred only
FTSJ1 covaries with ERLEC1ProteinHetionet hetionet:covaries:24140-27248Inferred only
ERLEC1 covaries with R3HDM4ProteinHetionet hetionet:covaries:27248-91300Inferred only
ERLEC1 covaries with RBM14ProteinHetionet hetionet:covaries:10432-27248Inferred only
SOX14 covaries with ERLEC1ProteinHetionet hetionet:covaries:27248-8403Inferred only
ERLEC1 covaries with SPRED3ProteinHetionet hetionet:covaries:27248-399473Inferred only
ERLEC1 covaries with SYT5ProteinHetionet hetionet:covaries:27248-6861Inferred only
ZNF331 covaries with ERLEC1ProteinHetionet hetionet:covaries:27248-55422Inferred only
OS9 interacts with ERLEC1ProteinHetionet hetionet:interacts:10956-27248Inferred only
SERPINA1 interacts with ERLEC1ProteinHetionet hetionet:interacts:27248-5265Inferred only

Show the remaining 22

UBC interacts with ERLEC1ProteinHetionet hetionet:interacts:27248-7316Inferred only
ERLEC1 participates in ABC transporter disordersPathwayReactome R-HSA-5619084Inferred only
ERLEC1 participates in ABC-family protein mediated transportPathwayReactome R-HSA-382556Inferred only
ERLEC1 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
ERLEC1 participates in AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)PathwayReactome R-HSA-9931269Inferred only
ERLEC1 participates in Co-inhibition by PD-1PathwayReactome R-HSA-389948Inferred only
ERLEC1 participates in Defective CFTR causes cystic fibrosisPathwayReactome R-HSA-5678895Inferred only
ERLEC1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
ERLEC1 participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
ERLEC1 participates in Disorders of transmembrane transportersPathwayReactome R-HSA-5619115Inferred only
ERLEC1 participates in Hedgehog ligand biogenesisPathwayReactome R-HSA-5358346Inferred only
ERLEC1 participates in Hh mutants abrogate ligand secretionPathwayReactome R-HSA-5387390Inferred only
ERLEC1 participates in Hh mutants are degraded by ERADPathwayReactome R-HSA-5362768Inferred only
ERLEC1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
ERLEC1 participates in Network map of SARS CoV 2 signalingPathwayWikiPathways WP5115Inferred only
ERLEC1 participates in Regulation of PD-L1(CD274) expressionPathwayReactome R-HSA-9909648Inferred only
ERLEC1 participates in Regulation of PD-L1(CD274) Post-translational modificationPathwayReactome R-HSA-9909615Inferred only
ERLEC1 participates in Regulation of T cell activation by CD28 familyPathwayReactome R-HSA-388841Inferred only
ERLEC1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ERLEC1 participates in Signaling by HedgehogPathwayReactome R-HSA-5358351Inferred only
ERLEC1 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
ERLEC1 regulates negative regulation of retrograde protein transport, ER to cytosolBiological processgene ontology Q96DZ1|GO:1904153Inferred only

Other names

5 names

Resolves to: ERLEC1

Also called: C2orf30ER lectinErlectinXTP3-transactivated gene B proteinXTP3TPB

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