Proteins/UNIPROT:Q9P2L0

WDR35

ProteinUNIPROT:Q9P2L0

As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. May promote CASP3 activation and TNF-stimulated apoptosis..

Function from UniProtKB (Q9P2L0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

asphyxiating thoracic dystrophy 3 has a germline basis in WDR35DiseaseGenCC HGNC:29250|MONDO:0013127Inferred only
cranioectodermal dysplasia has a germline basis in WDR35DiseaseGenCC HGNC:29250|MONDO:0009032Inferred only
cranioectodermal dysplasia 2 has a germline basis in WDR35DiseaseGenCC HGNC:29250|MONDO:0013323Inferred only
short-rib thoracic dysplasia 7 with or without polydactyly has a germline basis in WDR35DiseaseGenCC HGNC:29250|MONDO:0013569Inferred only

Statements

8 statements

8 statements · 2 reference databases · Subject: WDR35 · Sources: Hetionet, Reactome

Order

UBC interacts with WDR35ProteinHetionet hetionet:interacts:57539-7316Inferred only
WDR35 participates in Assembly of the 9+0 primary ciliumPathwayReactome R-HSA-9975921Inferred only
WDR35 participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
WDR35 participates in Hedgehog 'off' statePathwayReactome R-HSA-5610787Inferred only
WDR35 participates in Intraflagellar transportPathwayReactome R-HSA-5620924Inferred only
WDR35 participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
WDR35 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
WDR35 participates in Signaling by HedgehogPathwayReactome R-HSA-5358351Inferred only

Other names

4 names

Resolves to: WDR35

Also called: IFT121Intraflagellar transport protein 121 homologKIAA1336WD repeat-containing protein 35

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