N-(octadecanoyl)-sphinganine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

111 compounds within 3 steps: 2 in 1, 26 in 2, 83 in 3

Three steps

tetradecanoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes
(9Z)-octadecenoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 14 routes
hexacosanoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes
tetracosanoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes
an N-acyl-(4R)-4-hydroxysphinganineReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. a fatty acyl-CoA + sphinganine = an N-acylsphinganine + CoA + H(+)
3. dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)
Catalysed by ASAH2, CERS1, CERS6, CERS5 and 3 morecytosolOne of 2 routes
octadecan-1-olReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. octadecanoyl-CoA + 2 NADPH + 2 H(+) = octadecan-1-ol + 2 NADP(+) + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
eicosanoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes
(9Z)-hexadecenoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes
(15Z)-tetracosenoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes
(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes
(11Z)-eicosenoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes
an N-acylsphing-4-enineReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. a fatty acyl-CoA + sphinganine = an N-acylsphinganine + CoA + H(+)
3. delta 4-desaturase, sphingolipid (dihydroceramide pool)
Catalysed by ASAH2, CERS1, CERS6, CERS5 and 3 morecytosolOne of 5 routes
(9Z)-octadecenoyl-CoAReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
sphing-4-enineReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
Catalysed by ASAH2, ASAH1, ACER2
phosphoethanolamineReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. sphinganine + ATP = sphinganine 1-phosphate + ADP + H(+)
3. sphinganine 1-phosphate = hexadecanal + phosphoethanolamine
Catalysed by ASAH2, SPHK2, SPHK1, SGPL1
an acyl-CoAReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. acyl-CoA pool formation and breakdown
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 4 morecytosol
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes
1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositolReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
3-oxoeicosasphinganineReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. octadecanoyl-CoA + L-serine + H(+) = 3-oxoeicosasphinganine + CO2 + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 7 morecytosol
3-oxoeicosanoyl-CoAReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 11 morecytosolOne of 2 routes
an N-acylsphinganine-1-phosphocholineReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. a fatty acyl-CoA + sphinganine = an N-acylsphinganine + CoA + H(+)
3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
Catalysed by ASAH2, CERS1, CERS6, CERS5 and 3 more
(2E)-octadecenoyl-CoAReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 6 routes
(8Z,11Z,14Z)-eicosatrienoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
2-(9Z-octadecenoyl)-glycerolReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)
Catalysed by ASAH2, ABHD11
2-hydroxyoctadecanoyl-CoAReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. octadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctadecanoyl-CoA + succinate + CO2
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 10 morecytosol
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
Catalysed by ASAH2, ABHD11, DGKZ
1-octadecanoyl-sn-glycero-3-phosphateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 8 morecytosolOne of 2 routes
1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serineReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
(11Z)-octadecenoyl-CoAReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
1-octadecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
hexadecyl octadecanoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. hexadecan-1-ol + octadecanoyl-CoA = hexadecyl octadecanoate + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
(R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. Fatty Acid Beta Oxidation (C18:1->C18:1Oh), Mitochondrial
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 6 morecytosol, mitochondrial matrix
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)
3. 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)
Catalysed by ASAH2, ABHD11, DGKZ
(11Z,14Z)-eicosadienoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes
(17Z)-hexacosenoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes
1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. long-chain-fatty-acid-CoA ligase (stearate)
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by ASAH2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ASAH2cytosol, extracellular spaceOne of 12 routes
N-hexadecanoyl-sphinganine-1-phosphocholineReach from here →
1. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate
2. sphinganine + hexadecanoyl-CoA = N-hexadecanoylsphinganine + CoA + H(+)
3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
Catalysed by ASAH2, CERS6, CERS5, CERS2 and 2 more