N(tau)-methylhistamine

Three steps

• glutathione disulfideReach from here →
  1. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)
  2. transport of GSH and histamine (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by HNMT, SLCO1A2, SLCO1B3, GPX5 and 8 moreextracellular space, cytosolOne of 13 routes

• taurolithocholate 3-sulfateReach from here →
  1. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)
  2. transport of histamine (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by HNMT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-thyroxineReach from here →
  1. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)
  2. transport of histamine (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by HNMT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• S-sulfanylglutathioneReach from here →
  1. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)
  2. transport of GSH and histamine (cytosol to extracellular)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by HNMT, SLCO1A2, SLCO1B3, SQORextracellular space, cytosol, mitochondrial matrix

• dopamineReach from here →
  1. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)
  2. transport of histamine (cytosol to extracellular)
  3. transport of dopamine (cytosol to extracellular)

  Catalysed by HNMT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycolithocholate 3-sulfateReach from here →
  1. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)
  2. transport of histamine (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by HNMT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• estrone 3-sulfateReach from here →
  1. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)
  2. transport of histamine (cytosol to extracellular)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by HNMT, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• prostaglandin E2Reach from here →
  1. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)
  2. transport of histamine (cytosol to extracellular)
  3. transport of prostaglandin E2 (cytosol to extracellular)

  Catalysed by HNMT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-cysteinylglycineReach from here →
  1. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)
  2. transport of GSH and histamine (cytosol to extracellular)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by HNMT, SLCO1A2, SLCO1B3, GGTLC3 and 5 moreextracellular space, cytosolOne of 4 routes

• (R)-noradrenalineReach from here →
  1. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)
  2. transport of histamine (cytosol to extracellular)
  3. transport of noradrenaline (cytosol to extracellular)

  Catalysed by HNMT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)
  2. transport of histamine (cytosol to extracellular)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5

  Catalysed by HNMT, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• ursodeoxycholateReach from here →
  1. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)
  2. transport of histamine (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by HNMT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• prostaglandin G2Reach from here →
  1. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)
  2. transport of histamine (cytosol to extracellular)
  3. transport of prostaglandin G2 (cytosol to extracellular)

  Catalysed by HNMT, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• thromboxane B2Reach from here →
  1. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)
  2. transport of histamine (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by HNMT, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• taurochenodeoxycholateReach from here →
  1. histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)
  2. transport of histamine (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by HNMT, SLCO1A2, SLCO1B3, SLC7A9extracellular space, cytosolOne of 4 routes