thromboxane A2

Three steps

• L-thyroxineReach from here →
  1. thromboxane A2 hydrolysis
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)
  3. transport of GSH and thyroxine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3endoplasmic reticulum, extracellular space, cytosolOne of 4 routes

• S-sulfanylglutathioneReach from here →
  1. thromboxane A2 hydrolysis
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by SLCO1B1, SQORendoplasmic reticulum, extracellular space, cytosol, mitochondrial matrix

• dopamineReach from here →
  1. thromboxane A2 hydrolysis
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)
  3. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3endoplasmic reticulum, extracellular space, cytosolOne of 4 routes

• (2S)-2-phospholactateReach from here →
  1. thromboxane A2 hydrolysis
  2. thromboxane B2(out) + 2 (S)-lactate(in) = thromboxane B2(in) + 2 (S)-lactate(out)
  3. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

  Catalysed by SLCO2A1, PGPendoplasmic reticulum, inner side of the membrane, outer side of the membraneOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. thromboxane A2 hydrolysis
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)
  3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3endoplasmic reticulum, extracellular space, cytosolOne of 4 routes

• estrone 3-sulfateReach from here →
  1. thromboxane A2 hydrolysis
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by SLCO1B1endoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• prostaglandin E2Reach from here →
  1. thromboxane A2 hydrolysis
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)
  3. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3endoplasmic reticulum, extracellular space, cytosolOne of 6 routes

• L-cysteinylglycineReach from here →
  1. thromboxane A2 hydrolysis
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by SLCO1B1, GGTLC3, GGT1, GGT5 and 3 moreendoplasmic reticulum, extracellular space, cytosolOne of 4 routes

• (R)-noradrenalineReach from here →
  1. thromboxane A2 hydrolysis
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3endoplasmic reticulum, extracellular space, cytosolOne of 4 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. thromboxane A2 hydrolysis
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by SLCO1B1, SLCO2A1endoplasmic reticulum, extracellular space, cytosolOne of 4 routes

• ursodeoxycholateReach from here →
  1. thromboxane A2 hydrolysis
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3endoplasmic reticulum, extracellular space, cytosolOne of 4 routes

• prostaglandin G2Reach from here →
  1. thromboxane A2 hydrolysis
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO2A1endoplasmic reticulum, extracellular space, cytosolOne of 4 routes

• taurochenodeoxycholateReach from here →
  1. thromboxane A2 hydrolysis
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)
  3. solute carrier organic anion transporter (GSH)

  Catalysed by SLCO1B1, SLCO1A2, SLC7A9, SLCO1B3endoplasmic reticulum, extracellular space, cytosolOne of 4 routes