iron(2+)

Three steps

• Xaa-L-Pro dipeptideReach from here →
  1. De novo synthesis of 2Fe2S
  2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)
  3. Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, inner side of the membrane, outer side of the membrane

• 3',5'-diiodo-L-thyronineReach from here →
  1. De novo synthesis of 2Fe2S
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. De novo synthesis of 2Fe2S
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrixOne of 7 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. De novo synthesis of 2Fe2S
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrixOne of 3 routes

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. De novo synthesis of 2Fe2S
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrixOne of 3 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. L-Alanine:glyoxylate aminotransferase
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrixOne of 2 routes

• 3-iodothyronamineReach from here →
  1. De novo synthesis of 2Fe2S
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 11 moremitochondrial matrix, cytosolOne of 5 routes

• 3-iodo-L-thyronineReach from here →
  1. De novo synthesis of 2Fe2S
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrixOne of 2 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 11 moremitochondrial matrix, cytosolOne of 8 routes

• 3'-iodo-L-thyronineReach from here →
  1. De novo synthesis of 2Fe2S
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrixOne of 2 routes

• L-thyronineReach from here →
  1. De novo synthesis of 2Fe2S
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix

• thyronamineReach from here →
  1. De novo synthesis of 2Fe2S
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix

• 3'-iodothyronamineReach from here →
  1. De novo synthesis of 2Fe2S
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrixOne of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. De novo synthesis of 2Fe2S
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrixOne of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. De novo synthesis of 2Fe2S
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix

• 3,3',5'-triiodothyronamineReach from here →
  1. De novo synthesis of 2Fe2S
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. De novo synthesis of 2Fe2S
  2. L-Alanine:glyoxylate aminotransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 8 moremitochondrial matrixOne of 3 routes

• a quinolReach from here →
  1. De novo synthesis of 2Fe2S
  2. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)
  3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• hypochlorous acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and chloride (cytosol to extracellular)
  3. Peroxidase

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and chloride (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• phenylacetylglycineReach from here →
  1. De novo synthesis of 2Fe2S
  2. L-Alanine:glyoxylate aminotransferase
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, cytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 9 moremitochondrial matrix, cytosolOne of 6 routes

• CHEBI:27760Reach from here →
  1. De novo synthesis of 2Fe2S
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, cytosol

• elaidic acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 11 moremitochondrial matrix, cytosolOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. De novo synthesis of 2Fe2S
  2. L-Alanine:glyoxylate aminotransferase
  3. LTD4 hydrolysis

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, cytosol

• CHEBI:28701Reach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, peroxisomeOne of 7 routes

• 3-disulfanyl-L-alanineReach from here →
  1. De novo synthesis of 2Fe2S
  2. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, extracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosol

• Cu(2+)Reach from here →
  1. Fe(II):oxygen oxidoreductase
  2. Fe(3+)(out) + L-ascorbate(in) = monodehydro-L-ascorbate radical(in) + Fe(2+)(out) + H(+)
  3. Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + monodehydro-L-ascorbate radical(in) + H(+)

  Catalysed by CP, FTH1, FXN, FTMT and 6 moreextracellular space, inner side of the membrane, outer side of the membrane

• L-ascorbic acidReach from here →
  1. Fe(II):oxygen oxidoreductase
  2. Fe(3+)(out) + L-ascorbate(in) = monodehydro-L-ascorbate radical(in) + Fe(2+)(out) + H(+)
  3. a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by CP, FTH1, FXN, FTMT and 7 moreextracellular space, inner side of the membrane, outer side of the membraneOne of 9 routes

• K(+)Reach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• Cys-tRNA(Cys)Reach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, extracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. De novo synthesis of 2Fe2S
  2. L-Alanine:glyoxylate aminotransferase
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, cytosol

• Asp-tRNA(Asp)Reach from here →
  1. De novo synthesis of 2Fe2S
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and isoleucine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and glutamine (cytosol to extracellular)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 7 moremitochondrial matrix, extracellular space, cytosol

• isocyanateReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and citrulline (cytosol to extracellular)
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and asparagine (cytosol to extracellular)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosol

• hydrogenselenideReach from here →
  1. De novo synthesis of 2Fe2S
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix

• glycocholateReach from here →
  1. De novo synthesis of 2Fe2S
  2. L-Alanine:glyoxylate aminotransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, peroxisomeOne of 3 routes