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ReactionsRhea and Human-GEM, by subsystem
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AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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queuine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

13 compounds within 3 steps: 1 in 1, 3 in 2, 9 in 3

Does it reach a compound?

One step

guanineReach from here →
1. tRNA-guanosine34:queuine tRNA-D-ribosyltransferase
Catalysed by QTRT1, QTRT2cytosolOne of 2 routes

Two steps

guanosineReach from here →
1. tRNA-guanosine34:queuine tRNA-D-ribosyltransferase
2. guanosine:phosphate alpha-D-ribosyltransferase
Catalysed by QTRT1, QTRT2, PNPcytosol
2'-deoxyguanosineReach from here →
1. tRNA-guanosine34:queuine tRNA-D-ribosyltransferase
2. Deoxyguanosine:orthophosphate ribosyltransferase
Catalysed by QTRT1, QTRT2, PNPcytosolOne of 2 routes
xanthineReach from here →
1. tRNA-guanosine34:queuine tRNA-D-ribosyltransferase
2. Guanine aminohydrolase
Catalysed by QTRT1, QTRT2, GDAcytosolOne of 2 routes

Three steps

hypoxanthineReach from here →
Catalysed by QTRT1, QTRT2, GDA, XDHcytosol
inosineReach from here →
Catalysed by QTRT1

cytosol

One of 2 routes

urateReach from here →

tRNA-guanosine34:queuine tRNA-D-ribosyltransferase
Guanine aminohydrolase
xanthine:NAD+ oxidoreductase

Catalysed by QTRT1, QTRT2, GDA, XDHcytosolOne of 6 routes

xanthosineReach from here →

tRNA-guanosine34:queuine tRNA-D-ribosyltransferase
Guanine aminohydrolase
xanthosine:orthophosphate ribosyltransferase

Catalysed by QTRT1, QTRT2, GDA, PNPcytosolOne of 2 routes

D-ribose 1-phosphateReach from here →

tRNA-guanosine34:queuine tRNA-D-ribosyltransferase
guanosine:phosphate alpha-D-ribosyltransferase
guanosine:phosphate alpha-D-ribosyltransferase

Catalysed by QTRT1, QTRT2, PNPcytosol

2-deoxy-alpha-D-ribose 1-phosphateReach from here →

tRNA-guanosine34:queuine tRNA-D-ribosyltransferase
Deoxyguanosine:orthophosphate ribosyltransferase
2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine

Catalysed by QTRT1, QTRT2, PNPcytosol

XMPReach from here →

tRNA-guanosine34:queuine tRNA-D-ribosyltransferase
Guanine aminohydrolase
XMP:pyrophosphate phosphoribosyltransferase

Catalysed by QTRT1, QTRT2, GDA, HPRT1cytosol

dGMPReach from here →

tRNA-guanosine34:queuine tRNA-D-ribosyltransferase
Deoxyguanosine:orthophosphate ribosyltransferase
ATP:deoxyguanosine 5'-phosphotransferase

Catalysed by QTRT1, QTRT2, PNP, DGUOKcytosolOne of 4 routes

alpha-D-ribose 1-phosphateReach from here →

tRNA-guanosine34:queuine tRNA-D-ribosyltransferase
guanosine:phosphate alpha-D-ribosyltransferase
guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine

Catalysed by QTRT1, QTRT2, PNP, LACC1cytosol