anthranilate

Three steps

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by KYNU, KYAT3, AADAT, GLYATL2One of 2 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by KYNU, AADAT, PPCScytosolOne of 4 routes

• an N-acyl-L-amino acidReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)
  3. an N-acyl-L-amino acid + H2O = an L-alpha-amino acid + a carboxylate

  Catalysed by KYNU, SLC7A11, ACY1, PM20D1inner side of the membrane, outer side of the membrane

• L-prolineReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. L-Kynurenine hydrolase
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by KYNU, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-benzoylglycineReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by KYNU, KYAT3, AADATmitochondrial matrixOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by KYNU, AADAT, CDO1cytosolOne of 2 routes

• L-cysteinylglycineReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. L-Kynurenine hydrolase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by KYNU, GGTLC3, GGT1, GGT5 and 3 morecytosolOne of 2 routes

• xanthurenateReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  3. Kynurenine-Oxoglutarate Transaminase

  Catalysed by KYNU, KMO, AADATcytosol, mitochondrial matrixOne of 3 routes

• Mo-molybdopterinReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. L-Kynurenine hydrolase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by KYNU, MOCOScytosol

• an L-aminoacyl-L-amino acidReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)
  3. an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid

  Catalysed by KYNU, SLC7A11, DPEP1, DPEP2inner side of the membrane, outer side of the membrane

• thio-Mo-molybdopterinReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by KYNU, AADAT, MOCOS

• glycodeoxycholateReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. Glycodeoxycholate amidohydrolase

  Catalysed by KYNU, KYAT3, AADATcytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by KYNU, KYAT3, AADAT, GLYATL2

• N-eicosanoylglycinateReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by KYNU, KYAT3, AADAT, BAAT

• N-docosanoylglycineReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by KYNU, KYAT3, AADAT, BAAT

• N-hexacosanoylglycineReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by KYNU, KYAT3, AADAT, BAAT