ubiquinones

Three steps

• (3R)-citramalateReach from here →
  1. succinate:quinone oxidoreductase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SDHD, SDHB, SDHA, SDHC and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. succinate:quinone oxidoreductase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SDHD, SDHB, SDHA, SDHC and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• cis-aconitic acidReach from here →
  1. succinate:quinone oxidoreductase
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SDHD, SDHB, SDHA, SDHC and 2 moremitochondrial matrix, cytosolOne of 3 routes

• glyoxylateReach from here →
  1. succinate:quinone oxidoreductase
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by SDHD, SDHB, SDHA, SDHC and 2 moremitochondrial matrix, cytosol

• (S)-malyl-CoAReach from here →
  1. succinate:quinone oxidoreductase
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by SDHD, SDHB, SDHA, SDHC and 3 moremitochondrial matrix, cytosol

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. thioredoxin-disulfide reductase (NADPH) (ubiquinone)
  2. ubiquinol:ferricytochrome-c oxidoreductase
  3. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion

  Catalysed by NQO1, CBR1, UQCRQ, UQCR11 and 8 morecytosol, mitochondrial intermembrane space, mitochondrial matrix

• dihydroxyacetone phosphateReach from here →
  1. succinate:quinone oxidoreductase
  2. a quinone + succinate = fumarate + a quinol
  3. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol

  Catalysed by SDHD, SDHB, SDHA, SDHC and 1 moremitochondrial matrix

• N-sulfo-D-glucosamineReach from here →
  1. succinate:quinone oxidoreductase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SDHD, SDHB, SDHA, SDHC and 2 moremitochondrial matrix, cytosol

• dehydroepiandrosterone 3-sulfateReach from here →
  1. succinate:quinone oxidoreductase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by SDHD, SDHB, SDHA, SDHC and 2 moremitochondrial matrix, cytosol

• glutathioneReach from here →
  1. succinate:quinone oxidoreductase
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SDHD, SDHB, SDHA, SDHC and 2 moremitochondrial matrix, cytosolOne of 2 routes

• IMPReach from here →
  1. succinate:quinone oxidoreductase
  2. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  3. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)

  Catalysed by SDHD, SDHB, SDHA, SDHC and 4 moremitochondrial matrix, cytosol

• adenosine 5'-phosphosulfateReach from here →
  1. succinate:quinone oxidoreductase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. ATP:sulfate adenylyltransferase

  Catalysed by SDHD, SDHB, SDHA, SDHC and 3 moremitochondrial matrix, cytosolOne of 4 routes

• glutathione disulfideReach from here →
  1. succinate:quinone oxidoreductase
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SDHD, SDHB, SDHA, SDHC and 2 moremitochondrial matrix, cytosol

• 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. succinate:quinone oxidoreductase
  2. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by SDHD, SDHB, SDHA, SDHC and 1 moremitochondrial matrix, cytosolOne of 2 routes

• S-sulfanylglutathioneReach from here →
  1. succinate:quinone oxidoreductase
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)
  3. thiosulfate + glutathione = S-sulfanylglutathione + sulfite + H(+)

  Catalysed by SDHD, SDHB, SDHA, SDHC and 2 moremitochondrial matrix, cytosolOne of 3 routes

• estrone 3-sulfateReach from here →
  1. succinate:quinone oxidoreductase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)

  Catalysed by SDHD, SDHB, SDHA, SDHC and 2 moremitochondrial matrix, cytosol

• (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateReach from here →
  1. succinate:quinone oxidoreductase
  2. a quinone + succinate = fumarate + a quinol
  3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by SDHD, SDHB, SDHA, SDHC and 1 moremitochondrial matrix

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. succinate:quinone oxidoreductase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by SDHD, SDHB, SDHA, SDHC and 2 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• ubiquinol-10Reach from here →
  1. succinate:quinone oxidoreductase
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

  Catalysed by SDHD, SDHB, SDHA, SDHC and 2 moremitochondrial matrix, cytosol