cholesterol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

594 compounds within 3 steps: 41 in 1, 100 in 2, 453 in 3

Three steps

(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by SOAT2, SOAT1, CEL, LIPA and 6 morelysosome
5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. unspecific monooxygenase (arachidonate)
Catalysed by SOAT2, SOAT1, CEL, LIPA and 26 morelysosome, cytosolOne of 4 routes
17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. unspecific monooxygenase (arachidonate)
Catalysed by SOAT2, SOAT1, CEL, LIPA and 26 morelysosome, cytosolOne of 2 routes
16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome
an acyl-4'-phosphopantetheineReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
2. acyl-CoA:sphingosine N-acyltransferase
3. an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
Catalysed by GBA1, GBA2, ASAH1, ACER2 and 5 moreGolgi apparatus
(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by CH25H, AIFM1, PYROXD1, PTGS2One of 2 routes
(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by CH25H, AIFM1, PYROXD1, PTGS2One of 2 routes
all-trans-3,4-didehydroretinolReach from here →
1. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-3,4-didehydroretinol + 2 oxidized [adrenodoxin] + 2 H2O
Catalysed by CH25H, RETSAT, CYP27C1
all-trans-4-hydroxyretinolReach from here →
1. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-4-hydroxyretinol + 2 oxidized [adrenodoxin] + H2O
Catalysed by CH25H, RETSAT, CYP27C1
1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholineReach from here →
1. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
2. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by LCAT, TAFAZZIN, CYP2W1
1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholineReach from here →
1. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
2. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by LCAT, TAFAZZIN, CYP2W1
1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholineReach from here →
1. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
2. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by LCAT, TAFAZZIN, CYP2W1
1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholineReach from here →
1. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
2. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by LCAT, TAFAZZIN, CYP2W1
androsterone 3alpha-sulfateReach from here →
1. cholesterol + 3'-phosphoadenylyl sulfate = cholesterol sulfate + adenosine 3',5'-bisphosphate + H(+)
2. Cholesterol-sulfate sulfohydrolase
3. steroid sulfatase (androsterone sulfate)
Catalysed by SULT2B1, SULT1C2, STScytosolOne of 3 routes
prostaglandin G1Reach from here →
1. 1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (8Z,11Z,14Z)-eicosatrienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
2. Steryl-ester acylhydrolase
3. (8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1
Catalysed by LCAT, CEL, LIPA, PTGS2lysosome
prostaglandin G3Reach from here →
1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA
2. Steryl-ester acylhydrolase
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 = prostaglandin G3
Catalysed by SOAT2, CEL, LIPA, PTGS2lysosome
prostaglandin H3Reach from here →
1. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. prostaglandin G3 + AH2 = prostaglandin H3 + A + H2O
Catalysed by CH25H, AIFM1, PYROXD1, PTGS2
10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by SOAT2, SOAT1, CEL, LIPA and 2 morelysosome
13-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by CH25H, AIFM1, PYROXD1, PTGS2
9-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by CH25H, AIFM1, PYROXD1, PTGS2
(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate
Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome
(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate
Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome
2,4-dinitrophenyl-S-glutathioneReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. transport of arachidonate (cytosol to extracellular)
Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome, extracellular space, cytosolOne of 2 routes
N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
2. Steryl-ester acylhydrolase
3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O
Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O
Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome
N-(9Z-octadecenoyl)-L-leucineReach from here →
1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
2. Steryl-ester acylhydrolase
3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate
Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome
8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA
2. Steryl-ester acylhydrolase
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by SOAT2, CEL, LIPA, CYP2C9lysosome
11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA
2. Steryl-ester acylhydrolase
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by SOAT2, CEL, LIPA, CYP2C8 and 1 morelysosome
14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA
2. Steryl-ester acylhydrolase
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by SOAT2, CEL, LIPA, CYP2C8 and 1 morelysosome
7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. unspecific monooxygenase (arachidonate)
Catalysed by SOAT2, SOAT1, CEL, LIPA and 26 morelysosome, cytosolOne of 2 routes
13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. unspecific monooxygenase (arachidonate)
Catalysed by SOAT2, SOAT1, CEL, LIPA and 26 morelysosome, cytosolOne of 2 routes
(24S)-hydroxycholesterol 3,24-disulfateReach from here →
1. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
2. (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)
3. (24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)
Catalysed by CYP46A1, SULT2A1
13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome
(13R)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by CH25H, AIFM1, PYROXD1, PTGS1 and 1 more
a 3-(acyloxy)acyl derivative of bacterial toxinReach from here →
1. an acyl-CoA + cholesterol = a cholesterol ester + CoA
2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
3. a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)
Catalysed by SOAT2, SOAT1, CES1, LIPN and 3 more
5alpha-dihydrotestosterone sulfateReach from here →
1. cholesterol + 3'-phosphoadenylyl sulfate = cholesterol sulfate + adenosine 3',5'-bisphosphate + H(+)
2. Cholesterol-sulfate sulfohydrolase
3. steroid sulfatase (5-alpha-dihydrotestosterone)
Catalysed by SULT2B1, SULT1C2, STScytosolOne of 3 routes
16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. unspecific monooxygenase (arachidonate)
Catalysed by SOAT2, SOAT1, CEL, LIPA and 26 morelysosome, cytosol
2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by CH25H, AIFM1, PYROXD1, PTGS2
2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by CH25H, AIFM1, PYROXD1, PTGS2
2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by CH25H, AIFM1, PYROXD1, PTGS2
2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →
1. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O
Catalysed by CH25H, AIFM1, PYROXD1, PTGS2
2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →
1. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O
Catalysed by CH25H, AIFM1, PYROXD1, PTGS2
1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholineReach from here →
1. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
3. 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by LCAT, PRDX6, LPCAT3, LPCAT1 and 1 more
1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
3. 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by LCAT, PRDX6, LPCAT3, LPCAT1 and 1 more
1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamineReach from here →
1. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
3. 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
Catalysed by LCAT, PRDX6, LPCAT3, LPCAT1 and 1 more
all-trans-retinyl tetradecanoateReach from here →
1. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA
Catalysed by CH25H, RETSAT, AWAT2
an aryl sulfateReach from here →
1. cholesterol + 3'-phosphoadenylyl sulfate = cholesterol sulfate + adenosine 3',5'-bisphosphate + H(+)
2. Cholesterol-sulfate sulfohydrolase
3. an aryl sulfate + H2O = a phenol + sulfate + H(+)
Catalysed by SULT2B1, SULT1C2, STS, ARSL and 5 morecytosol
8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion
Catalysed by SOAT2, SOAT1, CEL, LIPAlysosome, cytosolOne of 2 routes
1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
2. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by LCAT, LPCAT3, MBOAT2, LPCAT1 and 1 more
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
2. sterol esterase (Cholesteryl Arachidonate)
3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine
Catalysed by SOAT2, SOAT1, CEL, LIPA and 2 morelysosome