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Proteins/UNIPROT:Q86VL8
Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney..
[Isoform 6]: Non-functional protein..
Function from UniProtKB (Q86VL8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
28 statements
28 statements · 6 reference databases · Subject: SLC47A2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
6 reactions
MAM02035e+protonMAM02035c+proton
Transported by SLC47A1 or SLC47A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09582CC BY 4.0Reference data
proton+metforminproton+metformin
Transported by SLC47A1 or SLC47A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
5 names
Resolves to: SLC47A2
Human-GEM MAR09584CC BY 4.0Reference data
creatinine+protoncreatinine+proton
Transported by SLC47A1 or SLC47A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09619CC BY 4.0Reference data
thiamine+hydronthiamine+hydron
Transported by SLC19A2 or SLC47A2 or SLC47A1 or SLC19A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:71271CC BY 4.0Reference data
estrone 3-sulfate+hydronestrone 3-sulfate+hydron
Transported by SLC47A2 or SLC47A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:72139CC BY 4.0Reference data
creatinine+hydroncreatinine+hydron
Transported by SLC47A2 or SLC47A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:72183CC BY 4.0Reference data