Loading the page.
Proteins/UNIPROT:Q96FL8
Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively. Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate. May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable)..
Function from UniProtKB (Q96FL8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
39 statements
39 statements · 7 reference databases · Subject: SLC47A1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
7 reactions
MAM02035e+protonMAM02035c+proton
Transported by SLC47A1 or SLC47A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09582CC BY 4.0Reference data
proton+metforminproton+metformin
Transported by SLC47A1 or SLC47A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
4 names
Resolves to: SLC47A1
Human-GEM MAR09584CC BY 4.0Reference data
creatinine+protoncreatinine+proton
Transported by SLC47A1 or SLC47A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09619CC BY 4.0Reference data
thiamine+hydronthiamine+hydron
Transported by SLC19A2 or SLC47A2 or SLC47A1 or SLC19A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:71271CC BY 4.0Reference data
agmatine+hydronagmatine+hydron
Transported by SLC47A1
Reaction pageReversibleBalanced
Rhea RHEA:72127CC BY 4.0Reference data
estrone 3-sulfate+hydronestrone 3-sulfate+hydron
Transported by SLC47A2 or SLC47A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:72139CC BY 4.0Reference data
creatinine+hydroncreatinine+hydron
Transported by SLC47A2 or SLC47A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:72183CC BY 4.0Reference data