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Proteins/UNIPROT:Q3KNW5

SLC10A6

Protein·UNIPROT:Q3KNW5Sodium-dependent organic anion transporter1 compound

Open in the graph

Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis. Steroid sulfate hormones are commonly considered to be biologically inactive metabolites, that may be activated by steroid sulfatases into free steroids. May play an important role by delivering sulfoconjugated steroids to specific target cells in reproductive organs (By similarity). May play a role transporting the estriol precursor 16alpha-hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) at the fetal blood vessel endothelium. Can also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes..

Function from UniProtKB (Q3KNW5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · transported by

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

sodium(1+)ElementCHEBI:29101Inferred only165 paths11 endpoints

What the reference databases state

Statements

40 statements

40 statements · 4 reference databases · Subject: SLC10A6 · Sources: Human Protein Atlas, Human-GEM, Reactome, Rhea

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SLC10A6 is expressed in breastAnatomyHuman Protein Atlas ENSG00000145283Inferred only
SLC10A6 is expressed in bronchusAnatomyHuman Protein Atlas ENSG00000145283Inferred only
SLC10A6 is expressed in esophagusAnatomyHuman Protein Atlas ENSG00000145283Inferred only
SLC10A6 is expressed in mouth mucosaAnatomyHuman Protein Atlas ENSG00000145283Inferred only
SLC10A6 is expressed in nasopharynxAnatomyHuman Protein Atlas ENSG00000145283Inferred only
SLC10A6 is expressed in prostate glandAnatomyHuman Protein Atlas ENSG00000145283Inferred only
SLC10A6 is expressed in stomachAnatomyHuman Protein Atlas ENSG00000145283Inferred only
SLC10A6 is expressed in tonsilAnatomyHuman Protein Atlas ENSG00000145283Inferred only
SLC10A6 is expressed in uterine cervixAnatomyHuman Protein Atlas ENSG00000145283Inferred only
SLC10A6 is expressed in vaginaAnatomyHuman Protein Atlas ENSG00000145283Inferred only
SLC10A6 is expressed in zone of skinAnatomyHuman Protein Atlas ENSG00000145283Inferred only
SLC10A6 participates in SLC-mediated bile acid transportPathwayReactome R-HSA-9958517Inferred only

Show the remaining 28

SLC10A6 participates in SLC-mediated transmembrane transportPathwayReactome R-HSA-425407Inferred only
SLC10A6 participates in SLC-mediated transport of organic anionsPathwayReactome R-HSA-9955298Inferred only
SLC10A6 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
16alpha-hydroxydehydroepiandrosterone 3-sulfate is transported by SLC10A6CompoundRhea RHEA:71391Inferred only
17beta-estradiol 3-sulfate is transported by SLC10A6CompoundRhea RHEA:71087Inferred only
5alpha-dihydrotestosterone sulfate is transported by SLC10A6CompoundRhea RHEA:71355Inferred only
androsterone 3alpha-sulfate is transported by SLC10A6CompoundRhea RHEA:71351Inferred only
dehydroepiandrosterone 3-sulfate is transported by SLC10A6CompoundRhea RHEA:71091Inferred only
estrone 3-sulfate is transported by SLC10A6CompoundRhea RHEA:71083Inferred only
pregnenolone sulfate is transported by SLC10A6CompoundRhea RHEA:71095Inferred only
sodium(1+) is transported by SLC10A6CompoundRhea RHEA:71087Inferred only
sodium(1+) is transported by SLC10A6CompoundHuman-GEM MAR09621Inferred only
sodium(1+) is transported by SLC10A6CompoundRhea RHEA:71083Inferred only
sodium(1+) is transported by SLC10A6CompoundRhea RHEA:71091Inferred only
sodium(1+) is transported by SLC10A6CompoundRhea RHEA:71095Inferred only
sodium(1+) is transported by SLC10A6CompoundRhea RHEA:71099Inferred only
sodium(1+) is transported by SLC10A6CompoundRhea RHEA:71275Inferred only
sodium(1+) is transported by SLC10A6CompoundRhea RHEA:71351Inferred only
sodium(1+) is transported by SLC10A6CompoundRhea RHEA:71355Inferred only
sodium(1+) is transported by SLC10A6CompoundRhea RHEA:71359Inferred only
sodium(1+) is transported by SLC10A6CompoundRhea RHEA:71363Inferred only
sodium(1+) is transported by SLC10A6CompoundRhea RHEA:71367Inferred only
sodium(1+) is transported by SLC10A6CompoundRhea RHEA:71371Inferred only
sodium(1+) is transported by SLC10A6CompoundRhea RHEA:71375Inferred only
sodium(1+) is transported by SLC10A6CompoundRhea RHEA:71391Inferred only
taurolithocholate 3-sulfate is transported by SLC10A6CompoundRhea RHEA:71275Inferred only
taurolithocholate 3-sulfate is transported by SLC10A6CompoundHuman-GEM MAR09621Inferred only
testosterone 17-sulfate is transported by SLC10A6CompoundRhea RHEA:71375Inferred only

Reactions

15 reactions

sodium(1+)+taurolithocholate 3-sulfatesodium(1+)+taurolithocholate 3-sulfate
Transported by SLC10A6
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09621CC BY 4.0Reference data
estrone 3-sulfate+2sodium(1+)estrone 3-sulfate+2sodium(1+)
Transported by SLC10A1 or SLC10A6

Other names

2 names

Resolves to: SLC10A6

Also called: SOATSolute carrier family 10 member 6

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Direction not asserted

Balanced

Rhea RHEA:71083CC BY 4.0Reference data

17beta-estradiol 3-sulfate+2sodium(1+)17beta-estradiol 3-sulfate+2sodium(1+)

Transported by SLC10A6

Reaction pageDirection not assertedBalanced

Rhea RHEA:71087CC BY 4.0Reference data

dehydroepiandrosterone 3-sulfate+2sodium(1+)dehydroepiandrosterone 3-sulfate+2sodium(1+)

Transported by SLC10A6

Reaction pageDirection not assertedBalanced

Rhea RHEA:71091CC BY 4.0Reference data

pregnenolone sulfate+2sodium(1+)pregnenolone sulfate+2sodium(1+)

Transported by SLC10A6

Reaction pageDirection not assertedBalanced

Rhea RHEA:71095CC BY 4.0Reference data

CHEBI:190287+2sodium(1+)CHEBI:190287+2sodium(1+)

Transported by SLC10A6

Reaction pageDirection not assertedBalanced

Rhea RHEA:71099CC BY 4.0Reference data

taurolithocholate 3-sulfate+2sodium(1+)taurolithocholate 3-sulfate+2sodium(1+)

Transported by SLC10A6

Reaction pageDirection not assertedBalanced

Rhea RHEA:71275CC BY 4.0Reference data

androsterone 3alpha-sulfate+2sodium(1+)androsterone 3alpha-sulfate+2sodium(1+)

Transported by SLC10A6

Reaction pageDirection not assertedBalanced

Rhea RHEA:71351CC BY 4.0Reference data

5alpha-dihydrotestosterone sulfate+2sodium(1+)5alpha-dihydrotestosterone sulfate+2sodium(1+)

Transported by SLC10A6

Reaction pageDirection not assertedBalanced

Rhea RHEA:71355CC BY 4.0Reference data

CHEBI:190469+2sodium(1+)CHEBI:190469+2sodium(1+)

Transported by SLC10A6

Reaction pageDirection not assertedBalanced

Rhea RHEA:71359CC BY 4.0Reference data

CHEBI:133742+2sodium(1+)CHEBI:133742+2sodium(1+)

Transported by SLC10A6

Reaction pageDirection not assertedBalanced

Rhea RHEA:71363CC BY 4.0Reference data

CHEBI:133729+2sodium(1+)CHEBI:133729+2sodium(1+)

Transported by SLC10A6

Reaction pageDirection not assertedBalanced

Rhea RHEA:71367CC BY 4.0Reference data

Show the remaining 3