NEURL3

E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity. Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7. Also inhibits hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2. Plays an essential role in TLR4-mediated activation of MAPK pathways by promoting 'Lys-48'-linked polyubiquitination of the phosphatase DUSP1/MKP1..

Function from UniProtKB (Q96EH8), read 2026-09-23. CC BY 4.0.