Proteins/UNIPROT:Q15049

MLC1

ProteinUNIPROT:Q15049

Transmembrane protein mainly expressed in brain astrocytes that may play a role in transport across the blood-brain and brain-cerebrospinal fluid barriers. Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. May function as regulatory protein of membrane protein complexes such as ion channels (Probable)..

Function from UniProtKB (Q15049), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

megalencephalic leukoencephalopathy with subcortical cysts has a germline basis in MLC1DiseaseGenCC HGNC:17082|MONDO:0011391Inferred only
megalencephalic leukoencephalopathy with subcortical cysts 1 has a germline basis in MLC1DiseaseGenCC HGNC:17082|MONDO:0024555Inferred only

Statements

22 statements

22 statements · 2 reference databases · Subject: MLC1 · Sources: gene ontology, Hetionet

Order

ADAMTSL2 covaries with MLC1ProteinHetionet hetionet:covaries:23209-9719Inferred only
MLC1 covaries with BAHCC1ProteinHetionet hetionet:covaries:23209-57597Inferred only
DACT2 covaries with MLC1ProteinHetionet hetionet:covaries:168002-23209Inferred only
MLC1 covaries with DBNDD1ProteinHetionet hetionet:covaries:23209-79007Inferred only
DIPK1B covaries with MLC1ProteinHetionet hetionet:covaries:138311-23209Inferred only
GAK covaries with MLC1ProteinHetionet hetionet:covaries:23209-2580Inferred only
GLDC covaries with MLC1ProteinHetionet hetionet:covaries:23209-2731Inferred only
MLC1 covaries with KCNQ2ProteinHetionet hetionet:covaries:23209-3785Inferred only
NOTCH1 covaries with MLC1ProteinHetionet hetionet:covaries:23209-4851Inferred only
SLC29A4 covaries with MLC1ProteinHetionet hetionet:covaries:222962-23209Inferred only
MLC1 covaries with SNED1ProteinHetionet hetionet:covaries:23209-25992Inferred only
SNX8 covaries with MLC1ProteinHetionet hetionet:covaries:23209-29886Inferred only

Show the remaining 10

MLC1 interacts with DAPK2ProteinHetionet hetionet:interacts:23209-23604Inferred only
TPT1 interacts with MLC1ProteinHetionet hetionet:interacts:23209-7178Inferred only
UBC interacts with MLC1ProteinHetionet hetionet:interacts:23209-7316Inferred only
MLC1 regulates positive regulation of intracellular transportBiological processgene ontology Q15049|GO:0032388Inferred only
MLC1 regulates regulation of response to osmotic stressBiological processgene ontology Q15049|GO:0047484Inferred only
ATP2C1 decreases the expression of MLC1ProteinHetionet hetionet:regulates:27032-23209Inferred only
GNAI2 increases the expression of MLC1ProteinHetionet hetionet:regulates:2771-23209Inferred only
MEGF9 increases the expression of MLC1ProteinHetionet hetionet:regulates:1955-23209Inferred only
PTK2B increases the expression of MLC1ProteinHetionet hetionet:regulates:2185-23209Inferred only
SRRT increases the expression of MLC1ProteinHetionet hetionet:regulates:51593-23209Inferred only

Other names

4 names

Resolves to: MLC1

Also called: KIAA0027Megalencephalic leukoencephalopathy with subcortical cysts protein 1Membrane protein MLC1WKL1

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