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Proteins/UNIPROT:P52849
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (By similarity). Exhibits N-deacetylase activity. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (By similarity). Plays a role in determining the extent and pattern of sulfation of heparan sulfate (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan. Essential for the biosynthesis of sulfated heparin in mast cells, thereby enabling proper secretory granule formation and storage of mast-cell proteases (By similarity)..
Function from UniProtKB (P52849), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
10 statements
10 statements · 4 reference databases · Subject: NDST2 · Sources: Bgee, Hetionet, Reactome, WikiPathways
2 reactions
4water+MAM02095g+43'-phospho-5'-adenylyl sulfate4acetate+4proton+MAM02082g+4adenosine 3',5'-bismonophosphate
Catalysed by NDST1 or NDST4 or NDST3 or NDST2
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.8Golgi apparatus
Human-GEM MAR07216CC BY 4.0Reference data
alpha-D-glucosaminyl-[heparan sulfate](n)
6 names
Resolves to: NDST2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:21980CC BY 4.0Reference data