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Proteins/UNIPROT:Q8WTS6
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Also has methyltransferase activity toward non-histone proteins such as CGAS, GLI3, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (By similarity). Acts as a positive regulator of smoothened signaling by mediating methylation of full-length GLI3, increasing GLI3 ability to bind DNA..
Function from UniProtKB (Q8WTS6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
135 statements
135 statements · 6 reference databases · Subject: SETD7 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Reactome, WikiPathways
9 reactions
9 names
Resolves to: SETD7
Reaction pageReversibleBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR04241CC BY 4.0Reference data
MAM00204c+S-adenosyl-L-methionineMAM00213c+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C or SETDB2 or SETD1B and 11 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354cytosol
Human-GEM MAR06975CC BY 4.0Reference data
MAM00213c+S-adenosyl-L-methionineMAM00212c+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C or SETDB2 or SETD1B and 11 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354cytosol
Human-GEM MAR06976CC BY 4.0Reference data
MAM00212c+S-adenosyl-L-methionineMAM00211c+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C or SETDB2 or SETD1B and 11 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354cytosol
Human-GEM MAR06977CC BY 4.0Reference data
MAM00204n+S-adenosyl-L-methionineproton+MAM02129n+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08025CC BY 4.0Reference data
MAM02129n+S-adenosyl-L-methionineMAM00212n+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08026CC BY 4.0Reference data
MAM00212n+S-adenosyl-L-methionineMAM00211n+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08027CC BY 4.0Reference data
L-lysyl-[protein]+S-adenosyl-L-methionineN(6)-methyl-L-lysyl-[protein]+S-adenosyl-L-homocysteine+hydron
Catalysed by EEF1AKMT4 or METTL21C or SMYD4 or METTL13 or SETD6 or SETD7 or EEF1AKMT3 or SETD2 or KMT5A or PRDM9 or SMYD2 or SETD4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:51736CC BY 4.0Reference data
L-lysyl(4)-[histone H3]+S-adenosyl-L-methionineN(6)-methyl-L-lysyl(4)-[histone H3]+S-adenosyl-L-homocysteine+hydron
Catalysed by KMT2D or SETD1A or KMT2A or KMT2C or SETD7 or SETD4 or KMT2B or SETD1B
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60264CC BY 4.0Reference data