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Proteins/UNIPROT:Q8TBK2
Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1). Required for the maintenance of embryonic stem cell self-renewal (By similarity). Methylates PAK4..
Function from UniProtKB (Q8TBK2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
9 statements
9 statements · 5 reference databases · Subject: SETD6 · Sources: Bgee, gene ontology, Hetionet, Reactome, WikiPathways
2 reactions
1 name
Resolves to: SETD6
Rhea RHEA:51736CC BY 4.0Reference data
L-lysyl(8)-[histone H2AZ]+S-adenosyl-L-methionineN(6)-methyl-L-lysyl(8)-[histone H2AZ]+S-adenosyl-L-homocysteine+hydron
Catalysed by SETD6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:67808CC BY 4.0Reference data