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Proteins/UNIPROT:Q8N6R0
Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation. Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2'. Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55'. Has no activity towards core histones H2A, H2B, H3 and H4..
Function from UniProtKB (Q8N6R0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
7 statements
7 statements · 1 reference database · Subject: METTL13 · Sources: Hetionet
3 reactions
6 names
Resolves to: METTL13
Rhea RHEA:51736CC BY 4.0Reference data
N(6)-methyl-L-lysyl-[protein]+S-adenosyl-L-methionineN(6),N(6)-dimethyl-L-lysyl-[protein]+S-adenosyl-L-homocysteine+hydron
Catalysed by EEF1AKMT4 or METTL21C or METTL13 or EEF1AKMT3 or PRDM9
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54196CC BY 4.0Reference data
N-terminal glycyl-L-lysyl-L-glutamyl-[protein]+3S-adenosyl-L-methionineN-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein]+3S-adenosyl-L-homocysteine+3hydron
Catalysed by METTL13
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:58440CC BY 4.0Reference data