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Proteins/UNIPROT:Q9NRG4
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'..
Function from UniProtKB (Q9NRG4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
46 statements
46 statements · 5 reference databases · Subject: SMYD2 · Sources: Bgee, gene ontology, Hetionet, Reactome, WikiPathways
2 reactions
5 names
Resolves to: SMYD2
Rhea RHEA:51736CC BY 4.0Reference data
L-lysyl(4)-[histone H3]+3S-adenosyl-L-methionineN(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3]+3S-adenosyl-L-homocysteine+3hydron
Catalysed by SMYD1 or SMYD3 or PRDM9 or SMYD2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60260CC BY 4.0Reference data