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Proteins/UNIPROT:Q96AZ1
Protein-lysine methyltransferase that selectively mono-, di- and trimethylates 'Lys-165' of the translation elongation factors EEF1A1 and EEF1A2 in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation..
Function from UniProtKB (Q96AZ1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 statements
4 statements · 1 reference database · Subject: EEF1AKMT3 · Sources: Hetionet
4 reactions
7 names
Resolves to: EEF1AKMT3
Rhea RHEA:51736CC BY 4.0Reference data
L-lysyl-[protein]+3S-adenosyl-L-methionineN(6),N(6),N(6)-trimethyl-L-lysyl-[protein]+3S-adenosyl-L-homocysteine+3hydron
Catalysed by EEF1AKMT2 or SMYD5 or ATPSCKMT or ETFBKMT or EEF1AKMT1 or METTL21A or EEF1AKMT3 or EEF2KMT or ANTKMT or METTL22 or SETD2 or VCPKMT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54192CC BY 4.0Reference data
N(6)-methyl-L-lysyl-[protein]+S-adenosyl-L-methionineN(6),N(6)-dimethyl-L-lysyl-[protein]+S-adenosyl-L-homocysteine+hydron
Catalysed by EEF1AKMT4 or METTL21C or METTL13 or EEF1AKMT3 or PRDM9
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54196CC BY 4.0Reference data
N(6),N(6)-dimethyl-L-lysyl-[protein]+S-adenosyl-L-methionineN(6),N(6),N(6)-trimethyl-L-lysyl-[protein]+S-adenosyl-L-homocysteine+hydron
Catalysed by EEF1AKMT4 or METTL21C or EEF1AKMT3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54200CC BY 4.0Reference data