Pathway
Mineralocorticoid biosynthesis
Aldosterone, the major human mineralocorticoid, is synthesized in the zona glomerulosa of the adrenal cortex from pregnenolone. Pregnenolone is converted to progesterone in two reactions, both catalyzed by 3-beta-hydroxysteroid dehydrogenase/isomerase. Progesterone is hydroxylated by CYP21A2 to form deoxycorticosterone, which in turn is converted to aldosterone in a three-reaction sequence catalyzed by CYP11B2.
REACT:R-HSA-193993Reactome
Also named: WP:5279
What the reference databases state
Statements
6 statements
6 statements · 1 reference database · Subject: Mineralocorticoid biosynthesis · Sources: Reactome
- CGA participates in Mineralocorticoid biosynthesisProteinReactome R-HSA-193993Inferred only
- CYP11B2 participates in Mineralocorticoid biosynthesisProteinReactome R-HSA-193993Inferred only
- CYP21A2 participates in Mineralocorticoid biosynthesisProteinReactome R-HSA-193993Inferred only
- HSD3B1 participates in Mineralocorticoid biosynthesisProteinReactome R-HSA-193993Inferred only
- HSD3B2 participates in Mineralocorticoid biosynthesisProteinReactome R-HSA-193993Inferred only
- LHB participates in Mineralocorticoid biosynthesisProteinReactome R-HSA-193993Inferred only