Pathway
Binding and Uptake of Ligands by Scavenger Receptors
Scavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). Some scavenger receptors, such as the CD163-haptoglobin system, are specific for only one ligand. Others, such as the SCARA receptors (SR-A receptors) are less specific, binding several ligands which share a common property, such as polyanionic charges.
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Brown and Goldstein originated the idea of receptors dedicated to scavenging aberrant molecules such as modified low density lipoprotein particles and such receptors have been shown to participate in pathological processes such as atherosclerosis. Based on homology, scavenger receptors have been categorized into classes A-H (reviewed in Murphy et al. 2005).
REACT:R-HSA-2173782Reactome
What the reference databases state
Statements
44 statements
44 statements · 1 reference database · Subject: Binding and Uptake of Ligands by Scavenger Receptors · Sources: Reactome
- ALB participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- AMBP participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- APOA1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- APOB participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- APOE participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- APOL1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- CALR participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- CD163 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- CD36 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- CD5L participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- COL1A1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- COL1A2 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
Show the remaining 32
- COL3A1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- COL4A1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- COL4A2 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- COLEC11 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- COLEC12 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- FTH1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- FTL participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- HBA1; HBA2 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- HBB participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- HMGB1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- HP participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- HPR participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- HPX participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- HSP90AA1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- HSP90B1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- HSPH1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- HYOU1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- JCHAIN participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- LRP1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- MARCO participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- MASP1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- MSR1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- PRDX1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- S100A9 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- SAA1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- SCARA5 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- SCARF1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- SCGB3A2 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- SPARC participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- SSC5D participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- STAB1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only
- STAB2 participates in Binding and Uptake of Ligands by Scavenger ReceptorsProteinReactome R-HSA-2173782Inferred only