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Proteins/UNIPROT:O14520
Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea. Mediates the efflux of glycerol, formed upon triglyceride hydrolysis, to avoid its accumulation in adipocytes and to make it available to other tissues. In the kidney, mediates the reabsorption of glycerol, preventing its loss in urine, again participating to energy homeostasis. In pancreatic beta cells, it also mediates the efflux of glycerol, regulating its intracellular levels (By similarity)..
Function from UniProtKB (O14520), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 6 reference databases · Subject: AQP7 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
6 reactions
7 names
Resolves to: AQP7
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04885CC BY 4.0Reference data
MAM01983e+waterMAM01983c+water
Transported by AQP9 or AQP10 or AQP7 or AQP3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09890CC BY 4.0Reference data
Transported by AQP7B or AQP12B or AQP7 or AQP9 or AQP8 or AQP1 or MIP or AQP2 or AQP5 or AQP4 or CLDN15 or CLDN2 and 5 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:29667CC BY 4.0Reference data
Transported by AQP7B or AQP7 or AQP9 or AQP1 or AQP2 or AQP11 or AQP3 or AQP10
Reaction pageDirection not assertedBalanced
Rhea RHEA:29675CC BY 4.0Reference data
Transported by AQP7 or AQP9 or SLC14A1 or SLC14A2 or AQP3 or AQP10
Reaction pageDirection not assertedBalanced
Rhea RHEA:32799CC BY 4.0Reference data