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Proteins/UNIPROT:P29972
Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues. Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol. In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo..
Function from UniProtKB (P29972), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
1 row
152 statements
152 statements · 8 reference databases · Subject: AQP1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
8 reactions
5 names
Resolves to: AQP1
Reaction pageDirection not assertedBalanced
Rhea RHEA:29463CC BY 4.0Reference data
Transported by AQP7B or AQP12B or AQP7 or AQP9 or AQP8 or AQP1 or MIP or AQP2 or AQP5 or AQP4 or CLDN15 or CLDN2 and 5 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:29667CC BY 4.0Reference data
Transported by AQP7B or AQP7 or AQP9 or AQP1 or AQP2 or AQP11 or AQP3 or AQP10
Reaction pageDirection not assertedBalanced
Rhea RHEA:29675CC BY 4.0Reference data
Transported by ANO9 or HTR3E or TMEM150C or KCNK1 or KCNK3 or GRIN2D or GRID2 or KCNQ3 or KCNQ2 or GRIN3B or HCN1 or TRPA1 and 98 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:34963CC BY 4.0Reference data
hydrogen peroxidehydrogen peroxide
Transported by AQP9 or AQP8 or AQP1 or AQP11 or AQP3
Reaction pageDirection not assertedBalanced
Rhea RHEA:74375CC BY 4.0Reference data
Transported by AQP1 or RHAG or AQP6 or RHBG or RHCG
Reaction pageLeft to rightBalanced
Rhea RHEA:74891CC BY 4.0Reference data
Transported by AQP1
Reaction pageDirection not assertedBalanced
Rhea RHEA:74895CC BY 4.0Reference data