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Proteins/UNIPROT:P54707
The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment. Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (By similarity). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance..
Function from UniProtKB (P54707), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
14 statements
14 statements · 4 reference databases · Subject: ATP12A · Sources: Hetionet, Human-GEM, Reactome, Rhea
4 reactions
ATP+water+potassium atom+2sodium(1+)ADP+proton+potassium atom+2sodium(1+)+phosphate(3-)
Reaction pageLeft to rightBalancedEC 7.2.2.19cytosol, extracellular space
Human-GEM MAR01444CC BY 4.0Reference data
ATP+
6 names
Resolves to: ATP12A
Reaction pageLeft to rightBalancedEC 7.2.2.19cytosol, extracellular space
Human-GEM MAR08892CC BY 4.0Reference data
2K(+)+3sodium(1+)+ATP(4-)+water2K(+)+3sodium(1+)+ADP(3-)+hydrogenphosphate+hydron
Transported by ATP1A1 or ATP1A3 or ATP1A2 or ATP12A or ATP1A4
Reaction pageLeft to rightBalanced
Rhea RHEA:18353CC BY 4.0Reference data
K(+)+ATP(4-)+water+hydronK(+)+ADP(3-)+hydrogenphosphate+2hydron
Transported by ATP4A or ATP12A
Reaction pageLeft to rightBalanced
Rhea RHEA:22044CC BY 4.0Reference data