Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy

MITF regulates biogenesis of organelles such as the lysosome and endosomes through its regulation of components of the V-ATPase that is required for organelle acidification and function (Zhang et al, 2015; Ploper et al, 2015a; reviewed in Ploper et al, 2015b). MITF-dependent targets also contribute to autophagy when cells are stressed for nutrients. MITF additionally controls expression of the lysosome-resident acid ceramidase ASAH1 that has roles in sphingolipid metabolism and cellular proliferation in melanoma.

Summary from Reactome (R-HSA-9857377), read 2026-09-23.