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Proteins/UNIPROT:Q13950
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation..
Function from UniProtKB (Q13950), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · inhibits
1 compound
1 compound.
0 reported routes1 assembled route
2 rows
74 statements
74 statements · 3 reference databases · Subject: RUNX2 · Sources: gene ontology, Hetionet, WikiPathways
1 paper
15 names
Resolves to: RUNX2