Pathway
HDL remodeling
HDL (high-density lipoprotein) particles play a central role in the reverse transport of cholesterol, the process by which cholesterol in tissues other than the liver is returned to the liver for conversion to bile salts and excretion from the body and provided to tissues such as the adrenals and gonads for steroid hormone synthesis.
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ABCG1 mediates the movement of intracellular cholesterol to the extracellular face of the plasma membrane where it is accessible to circulating HDL. Spherical (mature) HDL particles can acquire additional molecules of free cholesterol (CHOL) and phospholipid (PL) from cell membranes.
At the HDL surface, LCAT (lecithin-cholesterol acyltransferase) associates strongly with HDL particles and, activated by apoA-I, catalyzes the reaction of cholesterol and phosphatidylcholine to yield cholesterol esterified with a long-chain fatty acid and 2-lysophosphatidylcholine. The hydrophobic cholesterol ester reaction product is strongly associated with the HDL particle while the 2-lysophosphatidylcholine product is released. Torcetrapib associates with a molecule of CETP and a spherical HDL particle to form a stable complex, thus trapping CETP and inhibiting CETP-mediated lipid transfer between HDL and LDL.
Spherical HDL particles can bind apoC-II, apoC-III and and apoE proteins.
What the reference databases state
Statements
9 statements
9 statements · 1 reference database · Subject: HDL remodeling · Sources: Reactome
- ABCG1 participates in HDL remodelingProteinReactome R-HSA-8964058Inferred only
- ALB participates in HDL remodelingProteinReactome R-HSA-8964058Inferred only
- APOA1 participates in HDL remodelingProteinReactome R-HSA-8964058Inferred only
- APOC2 participates in HDL remodelingProteinReactome R-HSA-8964058Inferred only
- APOC3 participates in HDL remodelingProteinReactome R-HSA-8964058Inferred only
- APOE participates in HDL remodelingProteinReactome R-HSA-8964058Inferred only
- CETP participates in HDL remodelingProteinReactome R-HSA-8964058Inferred only
- LCAT participates in HDL remodelingProteinReactome R-HSA-8964058Inferred only
- LIPG participates in HDL remodelingProteinReactome R-HSA-8964058Inferred only