Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q6ZWL3

CYP4V2

Protein·UNIPROT:Q6ZWL3Cytochrome P450 4V21 compound

Open in the graph

A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs. Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)..

Function from UniProtKB (Q6ZWL3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · metabolized by

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

all-cis-docosa-4,7,10,13,16,19-hexaenoic acidCompoundCHEBI:28125Inferred only10 paths10 endpoints

What the reference databases state

GenCC submitters' classifications

1 row

Bietti crystalline corneoretinal dystrophy has a germline basis in CYP4V2DiseaseGenCC HGNC:23198|MONDO:0008865Inferred only

Statements

28 statements

28 statements · 7 reference databases · Subject: CYP4V2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Search this listOrder

CYP4V2 covaries with ABCG1ProteinHetionet hetionet:covaries:285440-9619Inferred only
KRTAP19-2 covaries with CYP4V2ProteinHetionet hetionet:covaries:285440-337969Inferred only
CYP4V2 is expressed in ileal mucosaAnatomyBgee ENSG00000145476Inferred only
CYP4V2 is expressed in liverAnatomyBgee ENSG00000145476Inferred only
SIN3A interacts with CYP4V2ProteinHetionet hetionet:interacts:25942-285440Inferred only
ZNF420 interacts with CYP4V2ProteinHetionet hetionet:interacts:147923-285440Inferred only
(1S)-1,25-dihydroxy-24-oxocalciol is metabolised by CYP4V2CompoundHuman-GEM MAR02144Inferred only
(1S)-1,25-dihydroxy-24-oxocalciol is metabolised by CYP4V2CompoundHuman-GEM MAR02145Inferred only
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate is metabolised by CYP4V2CompoundRhea RHEA:39791Inferred only
all-cis-docosa-4,7,10,13,16,19-hexaenoic acid is metabolised by CYP4V2CompoundRhea RHEA:40155Inferred only
calcidiol is metabolised by CYP4V2CompoundHuman-GEM MAR02130Inferred only
calcidiol is metabolised by CYP4V2CompoundHuman-GEM MAR02129Inferred only

Show the remaining 16

calcitetrol is metabolised by CYP4V2CompoundHuman-GEM MAR02143Inferred only
calcitetrol is metabolised by CYP4V2CompoundHuman-GEM MAR02142Inferred only
dodecanoate is metabolised by CYP4V2CompoundRhea RHEA:38947Inferred only
hexadecanoate is metabolised by CYP4V2CompoundRhea RHEA:40199Inferred only
tetradecanoate is metabolised by CYP4V2CompoundRhea RHEA:40203Inferred only
CYP4V2 participates in Biological oxidationsPathwayReactome R-HSA-211859Inferred only
CYP4V2 participates in Cytochrome P450 - arranged by substrate typePathwayReactome R-HSA-211897Inferred only
CYP4V2 participates in Endogenous sterolsPathwayReactome R-HSA-211976Inferred only
CYP4V2 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
CYP4V2 participates in Metapathway biotransformation Phase I and IIPathwayWikiPathways WP702Inferred only
CYP4V2 participates in Oxidation by cytochrome P450PathwayWikiPathways WP43Inferred only
CYP4V2 participates in Phase I - Functionalization of compoundsPathwayReactome R-HSA-211945Inferred only
CYP4V2 participates in Sensory PerceptionPathwayReactome R-HSA-9709957Inferred only
CYP4V2 participates in The canonical retinoid cycle in rods (twilight vision)PathwayReactome R-HSA-2453902Inferred only
CYP4V2 participates in Visual phototransductionPathwayReactome R-HSA-2187338Inferred only
CYP4V2 requires the cofactor hemeCompoundUniProt Q6ZWL3Inferred only

Reactions

17 reactions

calcidiol+proton+NADPH(4-)+dioxygenMAM00608c+water+NADP(3-)
Catalysed by COQ6 or CYP2E1 or CYP4V2
Reaction pageLeft to rightBalancedEC 1.14.13.-cytosol
Human-GEM MAR02129CC BY 4.0Reference data
MAM00608m+water+NADP(3-)

Other names

2 names

Resolves to: CYP4V2

Also called: Docosahexaenoic acid omega-hydroxylase CYP4V2Long-chain fatty acid omega-monooxygenase

← Every protein Find it in the graph →

Catalysed by COQ6 or CYP2E1 or CYP4V2

Reaction pageReversibleBalancedEC 1.14.13.-mitochondrial matrix

Human-GEM MAR02130CC BY 4.0Reference data

MAM00608c+proton+NADH(2-)+dioxygenMAM00607c+water+NAD(+)

Catalysed by COQ6 or CYP2E1 or CYP4V2

Reaction pageLeft to rightBalancedEC 1.14.13.-cytosol

Human-GEM MAR02131CC BY 4.0Reference data

MAM00608m+proton+NADH(2-)+dioxygenMAM00607m+water+NAD(+)

Catalysed by COQ6 or CYP2E1 or CYP4V2

Reaction pageLeft to rightBalancedEC 1.14.13.-mitochondrial matrix

Human-GEM MAR02132CC BY 4.0Reference data

MAM00607c+dioxygenMAM00621c+hydrogen peroxide

Catalysed by COQ6 or CYP2E1 or CYP4V2

Reaction pageLeft to rightBalancedEC 1.14.13.-cytosol

Human-GEM MAR02133CC BY 4.0Reference data

MAM00607m+dioxygenMAM00621m+hydrogen peroxide

Catalysed by COQ6 or CYP2E1 or CYP4V2

Reaction pageLeft to rightBalancedEC 1.14.13.-mitochondrial matrix

Human-GEM MAR02134CC BY 4.0Reference data

MAM00621c+dioxygenMAM00622c+hydrogen peroxide

Catalysed by COQ6 or CYP2E1 or CYP4V2

Reaction pageLeft to rightBalancedEC 1.14.13.-cytosol

Human-GEM MAR02135CC BY 4.0Reference data

MAM00621m+dioxygenMAM00622m+hydrogen peroxide

Catalysed by COQ6 or CYP2E1 or CYP4V2

Reaction pageLeft to rightBalancedEC 1.14.13.-mitochondrial matrix

Human-GEM MAR02136CC BY 4.0Reference data

calcitetrol+proton+NADPH(4-)+dioxygen(1S)-1,25-dihydroxy-24-oxocalciol+2water+NADP(3-)

Catalysed by COQ6 or CYP2E1 or CYP4V2

Reaction pageLeft to rightBalancedEC 1.14.13.-cytosol

Human-GEM MAR02142CC BY 4.0Reference data

calcitetrol+proton+NADPH(4-)+dioxygen(1S)-1,25-dihydroxy-24-oxocalciol+2water+NADP(3-)

Catalysed by COQ6 or CYP2E1 or CYP4V2

Reaction pageLeft to rightBalancedEC 1.14.13.-mitochondrial matrix

Human-GEM MAR02143CC BY 4.0Reference data

(1S)-1,25-dihydroxy-24-oxocalciol+proton+NADPH(4-)+dioxygenMAM00611c+water+NADP(3-)

Catalysed by COQ6 or CYP2E1 or CYP4V2

Reaction pageLeft to rightBalancedEC 1.14.13.-cytosol

Human-GEM MAR02144CC BY 4.0Reference data

(1S)-1,25-dihydroxy-24-oxocalciol+proton+NADPH(4-)+dioxygenMAM00611m+water+NADP(3-)

Catalysed by COQ6 or CYP2E1 or CYP4V2

Reaction pageLeft to rightBalancedEC 1.14.13.-mitochondrial matrix

Human-GEM MAR02145CC BY 4.0Reference data

Show the remaining 5