4-guanidinobutanoate

Three steps

• putrescineReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine
  3. L-ornithine carboxy-lyase (putrescine-forming)

  Catalysed by AGMAT, GATM, ODC1cytosolOne of 3 routes

• D-arginineReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by AGMAT, GATM, SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes

• (S)-lactic acidReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. Peroxidase
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by AGMAT, MPO, SLC22A12nucleus, extracellular space, cytosol

• taurineReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by AGMAT, SLC6A12, SLC6A6extracellular space, cytosolOne of 2 routes

• glycineReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by AGMAT, SLC6A12, SLC6A9, SLC6A14extracellular space, cytosolOne of 7 routes

• L-histidineReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. Formation of homocarnosine
  3. L-homocarnosine + H2O = 4-aminobutanoate + L-histidine

  Catalysed by AGMAT, CARNS1, CNDP1cytosolOne of 3 routes

• D-ornithineReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine
  3. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)

  Catalysed by AGMAT, GATM, SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes

• guanidinoacetateReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by AGMAT, SLC6A12extracellular space, cytosol

• L-methionineReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. transport of chloride and methionine (cytosol to extracellular)

  Catalysed by AGMAT, SLC6A12, SLC6A14extracellular space, cytosolOne of 4 routes

• L-tryptophanReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by AGMAT, SLC6A12, SLC6A14extracellular space, cytosolOne of 4 routes

• glutathioneReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. Peroxidase
  3. urate(out) + glutathione(in) = urate(in) + glutathione(out)

  Catalysed by AGMAT, MPO, SLC22A13nucleus, inner side of the membrane, outer side of the membrane

• beta-alanineReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by AGMAT, SLC6A12, SLC6A6, SLC6A14extracellular space, cytosolOne of 2 routes

• L-alanineReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by AGMAT, SLC6A12, SLC6A14extracellular space, cytosolOne of 5 routes

• L-asparagineReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. Transport of L-Asparagine by Atb0 Transporter

  Catalysed by AGMAT, SLC6A12, SLC6A14extracellular space, cytosolOne of 4 routes

• L-glutamate 5-semialdehydeReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine
  3. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

  Catalysed by AGMAT, GATM, OAT

• L-phenylalanineReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by AGMAT, SLC6A12, SLC6A14extracellular space, cytosolOne of 4 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine
  3. N(omega),N(omega)-dimethyl-L-arginine(in) + L-ornithine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-ornithine(in)

  Catalysed by AGMAT, GATM, SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-amino-2-oxopentanoateReach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by AGMAT, GATM, AGXT2One of 2 routes

• CHEBI:730073Reach from here →
  1. 4-guanidinobutanoate + H2O = urea + 4-aminobutanoate
  2. Peroxidase
  3. Peroxidase

  Catalysed by AGMAT, MPOnucleusOne of 3 routes