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Reach

(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

226 compounds within 3 steps: 4 in 1, 51 in 2, 171 in 3

Does it reach a compound?

Two steps

20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes
ursodeoxycholateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes
prostaglandin G2Reach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. transport of GSH and prostaglandin G2 (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes
thromboxane B2Reach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. transport of GSH and thromboxane B2 (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes
taurochenodeoxycholateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. solute carrier organic anion transporter (GSH)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol, extracellular spaceOne of 2 routes

Three steps

(S)-carnitineReach from here →
Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol, extracellular space, endoplasmic reticulumOne of 2 routes
CHEBI:1146900Reach from here →

Page 2 of 5

Catalysed by GPX5, GPX1, GPX2, GPX3 and 38 more

cytosol, extracellular space

One of 4 routes

AReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of GSH and thyroxine (cytosol to extracellular)
3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

Catalysed by GPX5, GPX1, GPX2, GPX3 and 9 morecytosol, extracellular spaceOne of 8 routes

(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 13 morecytosol, extracellular space

(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 13 morecytosol, extracellular space

(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 10 morecytosol, extracellular space

(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 12 morecytosol, extracellular space

(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular space

(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 11 morecytosol, extracellular space

5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 31 morecytosol, extracellular spaceOne of 4 routes

17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 31 morecytosol, extracellular spaceOne of 2 routes

16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular space

10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular space

prostaglandin J2Reach from here →

Glutathione: 15-HPETE oxidoreductase
transport of GSH and prostaglandin D2 (cytosol to extracellular)
prostaglandin J2 hydrolysis

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
15-keto-prostaglandin F2alpha reduction

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 4 routes

dopamine 3-O-sulfateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of dopamine and GSH (cytosol to extracellular)
dopamine + 3'-phosphoadenylyl sulfate = dopamine 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 11 morecytosol, extracellular space

dopamine 4-O-sulfateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of dopamine and GSH (cytosol to extracellular)
Dopamine 4-O-Sulfotransferase

Catalysed by GPX5, GPX1, GPX2, GPX3 and 9 morecytosol, extracellular spaceOne of 2 routes

prostaglandin A2-S-(R)-glutathioneReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of GSH and prostaglandin A2 (cytosol to extracellular)
prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol, extracellular space

prostaglandin A2-S-(S)-glutathioneReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of GSH and prostaglandin A2 (cytosol to extracellular)
prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol, extracellular space

(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular space

(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular space

2,4-dinitrophenyl-S-glutathioneReach from here →

Glutathione: 15-HPETE oxidoreductase
leukotriene C4 synthase (GSH)
transport of leukotriene C4 (cytosol to extracellular)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 76 routes

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular space

7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 31 morecytosol, extracellular spaceOne of 2 routes

13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 31 morecytosol, extracellular spaceOne of 2 routes

13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular space

16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 31 morecytosol, extracellular space

N-(4-oxoglutaryl)-L-cysteinylglycineReach from here →

Glutathione: 15-HPETE oxidoreductase
glutathione gamma-glutamylaminopeptidase
N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate

Catalysed by GPX5, GPX1, GPX2, GPX3 and 12 morecytosol

L-cystine-bis-glycineReach from here →

Glutathione: 15-HPETE oxidoreductase
glutathione gamma-glutamylaminopeptidase
2 L-cysteinylglycine + [protein]-disulfide = L-cystine-bis-glycine + [protein]-dithiol

Catalysed by GPX5, GPX1, GPX2, GPX3 and 12 morecytosol

8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol, extracellular spaceOne of 2 routes

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular space

(15S)-15-hydroperoxy-prostaglandin E2Reach from here →

Glutathione: 15-HPETE oxidoreductase
transport of GSH and prostaglandin G2 (cytosol to extracellular)
prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular space

cholineReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of acetylcholine and GSH (cytosol to extracellular)
Acetylcholine aectylhydrolase

Catalysed by GPX5, GPX1, GPX2, GPX3 and 9 morecytosol, extracellular spaceOne of 5 routes

pyruvateReach from here →

Glutathione: 15-HPETE oxidoreductase
cystine to cysteine conversion
L-cysteine hydrogen-sulfide-lyase (deaminating

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosolOne of 2 routes

arachidonoyl-CoAReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
Arachidonate:CoA ligase (AMP-forming)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 13 morecytosol, extracellular spaceOne of 3 routes

CHEBI:15519Reach from here →

Glutathione: 15-HPETE oxidoreductase
solute carrier organic anion transporter (cholate)
Cholate:CoA ligase (AMP-forming)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 9 morecytosol, extracellular space, endoplasmic reticulum

L-leucineReach from here →

Glutathione: 15-HPETE oxidoreductase
cystine to cysteine conversion
transport of cysteine and leucine (cytosol to extracellular)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 3 routes

12(S)-HPETEReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
arachidonate:oxygen 12-oxidoreductase

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 4 routes

5(S)-HPETEReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
Arachidonate:oxygen 5-oxidoreductase

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular space

CHEBI:15699Reach from here →

Glutathione: 15-HPETE oxidoreductase
cystine to cysteine conversion
transport of cysteine and homoserine (cytosol to extracellular)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 3 routes

formateReach from here →

Glutathione: 15-HPETE oxidoreductase
alcohol dehydrogenase (formaldehyde)
S-formylglutathione + H2O = formate + glutathione + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 12 morecytosol

CHEBI:15971Reach from here →

Glutathione: 15-HPETE oxidoreductase
cystine to cysteine conversion
transport of cysteine and histidine (cytosol to extracellular)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

(R)-lactateReach from here →

Glutathione: 15-HPETE oxidoreductase
(R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
(R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol

sulfateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of GSH and sulfoglycolithocholate (cytosol to extracellular)
steroid sulfatase (sulfoglycolithocholate)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol, extracellular space

L-cystineReach from here →

Glutathione: 15-HPETE oxidoreductase
Glutathione: 15-HPETE oxidoreductase
cystine to cysteine conversion

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 5 routes