(9Z,12Z)-octadecadienoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

348 compounds within 3 steps: 13 in 1, 47 in 2, 288 in 3

Three steps

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT3 and 3 moreOne of 3 routes
1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enineReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT3 and 3 more
1-O-alkyl-3-acylglycerolReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. acyl-CoA pool formation and breakdown
3. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA
Catalysed by ACSL3, ACSBG2, SLC27A3, MOGAT2 and 1 morecytosol
dodecanedioyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. Activation of dodecanedioic acid
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 4 morecytosolOne of 4 routes
decanedioyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. Production of Sebacoylcarnitine
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 7 morecytosolOne of 4 routes
octanedioyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. Production of Suberylcarnitine
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 7 morecytosolOne of 4 routes
hexanedioyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. Activation of adipic acid for Formation of Adipoyl Carnitine
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 4 morecytosolOne of 4 routes
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 10 morecytosolOne of 8 routes
(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 10 morecytosolOne of 6 routes
(R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. Production of 3-Hydroxyoctadecenoylcarnitinec
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 7 morecytosol
(13Z)-eicosenoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 10 morecytosolOne of 6 routes
4,8-dimethylnonanoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 6 morecytosol, peroxisomeOne of 3 routes
tetradecanedioyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 8 morecytosol, peroxisome
hexadecanedioyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. Production of Hexadecanedioylcarnitine
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 7 morecytosolOne of 2 routes
1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerolReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. 1-octadecanoyl-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
3. 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate
Catalysed by ACSL3, ACSBG2, SLC27A3, AGPAT4 and 1 more
pristanoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. fatty-acid-CoA ligase
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 5 morecytosolOne of 2 routes
a 1,3-diacyl-sn-glycerolReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. acyl-CoA pool formation and breakdown
3. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA
Catalysed by ACSL3, ACSBG2, SLC27A3, MOGAT1cytosolOne of 2 routes
a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. acyl-CoA pool formation and breakdown
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT2 and 1 morecytosol
a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. acyl-CoA pool formation and breakdown
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT4cytosol
1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. Beta Oxidation of Fatty Acid
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by ACSL3, ACSBG2, SLC27A3, ACADM and 2 moremitochondrial matrix
undecanoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. medium-chain acyl-CoA ligase (undecylic acid)
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 10 morecytosolOne of 3 routes
9-cis-retinolReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. retinol binding protein (retinol)
Catalysed by PTGS2, RETSAT, RBP1, RBP2cytosolOne of 2 routes
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by PTGS2, AIFM1, PYROXD1
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by PTGS2, AIFM1, PYROXD1
hexadecanoateReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT3 and 4 more
thio-Mo-molybdopterinReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by PTGS2, AIFM1, PYROXD1, MOCOSOne of 3 routes
(24S)-hydroxycholesterol 3-linoleoateReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
3. (24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT3 and 3 more
1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerolReach from here →
1. 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)
2. 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)
3. 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by PLA2G6, PNPLA8, HADHA
1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)
2. 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)
3. 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by PLA2G6, PNPLA8, HADHA
(5Z)-tetradecenoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. long-chain-fatty-acid-CoA ligase (physeteric acid)
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 10 morecytosolOne of 9 routes
(3E)-decenoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 8 morecytosol, mitochondrial matrix
2-glyceryl-prostaglandin H2Reach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
Catalysed by PTGS2, AIFM1, PYROXD1
1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphateReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. 1-octadecanoyl-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
3. 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
Catalysed by ACSL3, ACSBG2, SLC27A3, AGPAT4 and 2 more
(2R,6)-dimethylheptanoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 7 morecytosol, mitochondrial matrix
an N(2)-acyl-L-glutamineReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. acyl-CoA pool formation and breakdown
3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
Catalysed by ACSL3, ACSBG2, SLC27A3, GLYATL1B and 1 morecytosol
(7Z)-hexadecenoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 10 morecytosolOne of 9 routes
tricosanoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 10 morecytosolOne of 5 routes
a 3-oxoacyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. acyl-CoA pool formation and breakdown
3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
Catalysed by ACSL3, ACSBG2, SLC27A3, ACAA1 and 3 morecytosol
prostaglandin H1Reach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O
Catalysed by PTGS2, AIFM1, PYROXD1
(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by PTGS2, AIFM1, PYROXD1
(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by PTGS2, AIFM1, PYROXD1
(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by PTGS2, AIFM1, PYROXD1
17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
Catalysed by PTGS2, AIFM1, PYROXD1
13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoateReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
Catalysed by PTGS2, AIFM1, PYROXD1
(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by PTGS2, AIFM1, PYROXD1
(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by PTGS2, AIFM1, PYROXD1
(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoateReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O
Catalysed by PTGS2, AIFM1, PYROXD1
13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoateReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
Catalysed by PTGS2, AIFM1, PYROXD1