Catalyst

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Search ?

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

Reach

acetate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

454 compounds within 3 steps: 21 in 1, 106 in 2, 327 in 3

Does it reach a compound?

Two steps

1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
Catalysed by ASAH1, PLA2G15
1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by ASAH1, PLA2G15One of 4 routes
1-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
Catalysed by ASAH1, PLA2G15One of 3 routes
1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
Catalysed by ASAH1, PLA2G15One of 3 routes
4-acetamidobutanalReach from here →
1. N-acetylputrescine + H2O = putrescine + acetate
2. N-Acetylputrescine:oxygen oxidoreductase(deaminating)(flavin-containing)
Catalysed by HDAC10, AOC2, AOC1, MAOA and 2 morecytosolOne of 2 routes
1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by ASAH1, PLA2G15One of 8 routes
2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by ASAH1, PLA2G15One of 2 routes
1-octadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by ASAH1, PLA2G15One of 5 routes
2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-octadecanoyl-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
Catalysed by ASAH1, PLA2G15
1-hexadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by ASAH1, PLA2G15One of 9 routes
2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by ASAH1, PLA2G15
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
Catalysed by ASAH1, PLA2G15One of 2 routes
1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by ASAH1, PLA2G15One of 3 routes
2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by ASAH1, PLA2G15
2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by ASAH1, PLA2G15
1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by ASAH1, PLA2G15One of 3 routes
1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by ASAH1, PLA2G15
2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by ASAH1, PLA2G15
2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by ASAH1, PLA2G15
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by ASAH1, PLA2G15
16alpha,17alpha-dihydroxyprogesteroneReach from here →
1. cytochrome P450 (17alpha-hydroxyprogesterone)
2. 17alpha-hydroxyprogesterone + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha,17alpha-dihydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CYP17A1endoplasmic reticulum
2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-O-acyl-N-(acetyl)-sphing-4-enine
Catalysed by ASAH1, PLA2G15
2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine
Catalysed by ASAH1, PLA2G15
1-octadecanoyl-sn-glycero-3-phosphoserineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phosphoserine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
Catalysed by ASAH1, PLA2G15
1-O-acyl-N-(acetyl)-sphing-4-enineReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine
Catalysed by ASAH1, PLA2G15One of 8 routes
N-(acetyl)-sphing-4-enine-1-phosphateReach from here →
1. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
2. N-(acetyl)-sphing-4-enine + ATP = N-(acetyl)-sphing-4-enine-1-phosphate + ADP + H(+)
Catalysed by ASAH1, CERK
2-(1-hydroxyethyl)thiamine diphosphateReach from here →
1. transport of acetate and pyruvate (cytosol to extracellular)
2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 4 moreextracellular space, cytosol, mitochondrial matrix

Three steps

(S)-carnitineReach from here →
Catalysed by SLC16A4, SLC16A5, SLC16A1, SLC26A4 and 1 moreextracellular space, cytosolOne of 5 routes
CHEBI:1146900Reach from here →

Page 3 of 10

Catalysed by SLC16A4, SLC16A5, SLC16A6, SLC16A7 and 3 moreextracellular space, cytosolOne of 29 routes

N(omega)-methyl-L-arginineReach from here →

transport of acetate and pyruvate (cytosol to extracellular)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

3-hydroxy-2-methylpropanoateReach from here →

transport of acetate and pyruvate (cytosol to extracellular)
(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

AReach from here →

N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by ASAH1, PLA2G15, PTGS2One of 3 routes

S-butanoyl-4'-phosphopantetheineReach from here →

transport of acetate and butyrate (cytosol to extracellular)
Butanoate:CoA ligase (AMP-forming)
butanoyl-CoA + H2O = S-butanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A1 and 9 moreextracellular space, cytosol

1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholineReach from here →

N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ASAH1, PLA2G15, CYP2W1

1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholineReach from here →

N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ASAH1, PLA2G15, CYP2W1

1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholineReach from here →

N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ASAH1, PLA2G15, CYP2W1

1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholineReach from here →

N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ASAH1, PLA2G15, CYP2W1

prostaglandin A2-S-(R)-glutathioneReach from here →

transport of acetate and L-lactate (cytosol to extracellular)
Transport of Prostaglandin A2, Lactate Antiport
prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 4 moreextracellular space, cytosol

prostaglandin A2-S-(S)-glutathioneReach from here →

transport of acetate and L-lactate (cytosol to extracellular)
Transport of Prostaglandin A2, Lactate Antiport
prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 4 moreextracellular space, cytosol

prostaglandin J2-S-(R)-glutathioneReach from here →

transport of acetate and L-lactate (cytosol to extracellular)
Transport of Prostaglandin J2, Lactate Antiport
prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 5 moreextracellular space, cytosol

prostaglandin J2-S-(S)-glutathioneReach from here →

transport of acetate and L-lactate (cytosol to extracellular)
Transport of Prostaglandin J2, Lactate Antiport
prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 4 moreextracellular space, cytosol

2,4-dinitrophenyl-S-glutathioneReach from here →

transport of acetate and L-lactate (cytosol to extracellular)
Transport of Prostaglandin A2, Lactate Antiport
transport of prostaglandin A2 (cytosol to extracellular)

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosolOne of 4 routes

all-trans-4-oxoretinoateReach from here →

transport of acetate and retinoate (cytosol to extracellular)
cytochrome P450 (retinoate)
cytochrome P450 (4-hydroxy-all-trans-retinoate)

Catalysed by SLC16A4, SLC16A5, SLC16A7, CYP26A1 and 1 moreextracellular space, cytosolOne of 3 routes

6beta,16alpha,17alpha-trihydroxyprogesteroneReach from here →

cytochrome P450 (17alpha-hydroxyprogesterone)
17alpha-hydroxyprogesterone + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha,17alpha-dihydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
16alpha,17alpha-dihydroxyprogesterone + reduced [NADPH--hemoprotein reductase] + O2 = 6beta,16alpha,17alpha-trihydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP17A1endoplasmic reticulum

2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by ASAH1, PLA2G15, PTGS2

2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by ASAH1, PLA2G15, PTGS2

2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by ASAH1, PLA2G15, PTGS2

2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamineReach from here →

N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine

Catalysed by ASAH1, PLA2G15, PTGS2

2-(prostaglandin G2)-sn-glycero-3-phosphocholineReach from here →

N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphocholine

Catalysed by ASAH1, PLA2G15, PTGS2

all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoateReach from here →

transport of acetate and retinoate (cytosol to extracellular)
cytochrome P450 (retinoate)
all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate = all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + UDP + H(+)

Catalysed by SLC16A4, SLC16A5, SLC16A7, CYP26A1 and 1 moreextracellular space, cytosol