L-sepiapterin

Three steps

• thiosulfateReach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

  Catalysed by SLC22A6, SLC22A8, SLC25A35, SLC25A34 and 4 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• (S)-lactic acidReach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by SLC22A6, SLC22A8, SLC22A12inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• (6R)-L-erythro-6,7-dihydrobiopterinReach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)
  3. 1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O

  Catalysed by SLC22A6, SLC22A8, AGMOinner side of the membrane, outer side of the membrane

• glycineReach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  3. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)

  Catalysed by SLC22A6, SLC22A8, GLYATinner side of the membrane, outer side of the membrane

• benzoyl-CoAReach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  3. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)

  Catalysed by SLC22A6, SLC22A8, GLYATinner side of the membrane, outer side of the membrane

• 15-oxoprostaglandin E2Reach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)
  3. prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)

  Catalysed by SLC22A6, SLC22A8, HPGDinner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin H2Reach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  3. prostaglandin-F synthase (prostaglandin F2alpha)

  Catalysed by SLC22A6, SLC22A8inner side of the membrane, outer side of the membrane, cytosolOne of 4 routes

• prostaglandin D2Reach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  3. aldo-keto reductase (prostaglandin D2)

  Catalysed by SLC22A6, SLC22A8, AKR1C3inner side of the membrane, outer side of the membrane, cytosol

• L-dopaReach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa

  Catalysed by SLC22A6, SLC22A8, THinner side of the membrane, outer side of the membrane

• N-sulfo-D-glucosamineReach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SLC22A6, SLC22A8, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membrane

• dehydroepiandrosterone 3-sulfateReach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by SLC22A6, SLC22A8, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membrane

• glutathioneReach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  3. urate(out) + glutathione(in) = urate(in) + glutathione(out)

  Catalysed by SLC22A6, SLC22A8, SLC22A13inner side of the membrane, outer side of the membrane

• adenosine 5'-phosphosulfateReach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. ATP:sulfate adenylyltransferase

  Catalysed by SLC22A6, SLC22A8, SLC25A35, SLC25A34 and 2 moreinner side of the membrane, outer side of the membrane, cytosolOne of 4 routes

• L-tyrosineReach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by SLC22A6, SLC22A8, PAHinner side of the membrane, outer side of the membrane

• estrone 3-sulfateReach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)

  Catalysed by SLC22A6, SLC22A8, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membrane

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by SLC22A6, SLC22A8, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• methyl (indol-3-yl)acetateReach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)
  3. S-adenosyl-L-methionine:(indol-3-yl)acetate O-methyltransferase

  Catalysed by SLC22A6, SLC22A8, COMT, LRTOMTinner side of the membrane, outer side of the membrane, cytosol

• CHEBI:730073Reach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  3. Peroxidase

  Catalysed by SLC22A6, SLC22A8, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

• a 1-(1-hydroxyalkyl)-sn-glycerolReach from here →
  1. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)
  3. 1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O

  Catalysed by SLC22A6, SLC22A8, AGMOinner side of the membrane, outer side of the membrane