Proteins/UNIPROT:O00476

SLC17A3

ProteinUNIPROT:O00476Sodium-dependent phosphate transport protein 4

Mediates the renal excretion of uremic toxin 3-indoxyl sulfate..

[Isoform 2]: Transports organic anions in a voltage-driven, multispecific, manner, on the apical side of renal proximal tubule. In particular, participates in the secretion of urate from the cell into the lumen. Urate is the end product of purine metabolism. May have roles in the metabolism and secretion of estrone sulfate, estradiol-17-beta-glucuronide, ochratoxin A, as wells as drugs such as bumetanide..

Function from UniProtKB (O00476), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

18 statements

18 statements · 4 reference databases · Subject: SLC17A3 · Sources: Hetionet, Human-GEM, Reactome, Rhea

Order

SLC17A3 covaries with COL6A3ProteinHetionet hetionet:covaries:10786-1293Inferred only
SLC17A3 covaries with CRACDProteinHetionet hetionet:covaries:10786-57482Inferred only
SLC17A3 covaries with DEXIProteinHetionet hetionet:covaries:10786-28955Inferred only
SLC17A3 covaries with GLYATProteinHetionet hetionet:covaries:10249-10786Inferred only
SLC17A3 covaries with GPRIN1ProteinHetionet hetionet:covaries:10786-114787Inferred only
MILR1 covaries with SLC17A3ProteinHetionet hetionet:covaries:10786-284021Inferred only
SLC17A3 covaries with SMG7ProteinHetionet hetionet:covaries:10786-9887Inferred only
SLC17A3 covaries with SPC24ProteinHetionet hetionet:covaries:10786-147841Inferred only
SLC17A3 participates in Ion channel transportPathwayReactome R-HSA-983712Inferred only
SLC17A3 participates in Stimuli-sensing channelsPathwayReactome R-HSA-2672351Inferred only
SLC17A3 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
indoxyl sulfate is transported by SLC17A3CompoundRhea RHEA:82891Inferred only

Show the remaining 6

phosphate(3-) is transported by SLC17A3CompoundHuman-GEM MAR04910Inferred only
phosphate(3-) is transported by SLC17A3CompoundHuman-GEM MAR05342Inferred only
proton is transported by SLC17A3CompoundHuman-GEM MAR05342Inferred only
sodium(1+) is transported by SLC17A3CompoundRhea RHEA:72383Inferred only
sodium(1+) is transported by SLC17A3CompoundHuman-GEM MAR04910Inferred only
urate is transported by SLC17A3CompoundRhea RHEA:72383Inferred only

Reactions

4 reactions

3sodium(1+)+phosphate(3-)3sodium(1+)+phosphate(3-)
Transported by SLC17A2 or SLC17A3 or SLC17A1 or SLC34A1 or SLC17A4 or SLC20A1 or SLC20A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04910CC BY 4.0Reference data
proton+phosphate(3-)

Other names

4 names

Resolves to: SLC17A3

Also called: Na(+)/PI cotransporter 4NPT4Sodium/phosphate cotransporter 4Solute carrier family 17 member 3

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