Papers/PMID:36316858
Prophylactic melatonin for delirium in critically ill patients: A systematic review and meta-analysis with trial sequential analysis.
Medicine2022The record
1 finding · 1 compound · 1 endpoint · 1 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
1 finding
melatonin — no detected effect on all-cause mortality
StrongEvidence strength: strong. Randomised human trials or their synthesis, with the effect's size and interval recorded and no recorded weakness outstanding.FindingNull resultreplicated ×2“We found no significant difference in mortality between patients receiving melatonin and those receiving placebo (RR, 0.90; 95% CI: 0.77–1.06; I2 = 0%).”
Quoted verbatim from Prophylactic melatonin for delirium in critically ill patients: A systematic review and meta-analysis with trial sequential analysis.. - Study
- meta-analysis
- Participants
- 2,350
- Population
- Adult ICU patients; secondary endpoint, 10 trials, longest reported follow-up
Effect 0.9 risk ratio, 95% CI 0.77 to 1.06
Prophylactic melatonin for delirium in critically ill patients: A systematic review and meta-analysis with trial sequential analysis.2022PMID:36316858Permalink