Papers/PMID:36316858
Prophylactic melatonin for delirium in critically ill patients: A systematic review and meta-analysis with trial sequential analysis.
Medicine2022The record
1 finding drawn from this paper, on 1 compound across 1 endpoint, 1 of them null.
What it reported
How to read these marksEvery finding here is a null result.
What did not
1 finding
melatonin — no detected effect on all-cause mortality
LikelyGrade B, Likely. Human evidence, limited replication or design limits.FindingNull resultreplicated ×1“We found no significant difference in mortality between patients receiving melatonin and those receiving placebo (RR, 0.90; 95% CI: 0.77–1.06; I2 = 0%).”
Quoted verbatim from Prophylactic melatonin for delirium in critically ill patients: A systematic review and meta-analysis with trial sequential analysis.. - Study
- meta-analysis
- Participants
- 2,350
- Population
- Adult ICU patients; secondary endpoint, 10 trials, longest reported follow-up
Effect 0.9 risk ratio, 95% CI 0.77 to 1.06
Prophylactic melatonin for delirium in critically ill patients: A systematic review and meta-analysis with trial sequential analysis.2022PMID:36316858