Papers/PMID:38965577
Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials.
Journal of ovarian research2024The record
2 findings drawn from this paper, on 1 compound across 2 endpoints, 1 of them null.
What it reported
How to read these marksWhat moved
1 finding
melatonin — increases total antioxidant capacity
LikelyGrade B, Likely. Human evidence, limited replication or design limits.Findingreplicated ×1“Our meta-analysis indicated that melatonin intake significantly increase TAC levels (SMD: 0.87, 95% CI: 0.46, 1.28, I2 = 00.00%) compare to placebo (Table 2).”
Quoted verbatim from Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials.. - Study
- meta-analysis
- Dose
- 3-10 mg/day oral
- Population
- women with polycystic ovary syndrome; 6 double-blind RCTs
Effect 0.87 standardised mean difference, 95% CI 0.46 to 1.28
What did not
1 finding
melatonin — no detected effect on body mass index
LikelyGrade B, Likely. Human evidence, limited replication or design limits.FindingNull result“The results of random-effect meta-analysis indicated that melatonin intake has no effect on weight (SMD: −0.03, 95% CI: −0.30, 0.25, I2 = 00.00%) and BMI (SMD: −0.03, 95% CI: −0.30, 0.25, I2 = 00.00%) in patients with PCOS (Fig..).”
Quoted verbatim from Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials.. - Study
- meta-analysis
- Dose
- 3-10 mg/day oral
- Population
- women with polycystic ovary syndrome; 6 double-blind RCTs
Effect -0.03 standardised mean difference, 95% CI -0.3 to 0.25