Papers/PMID:28368352
Melatonin Pharmacological Blood Levels Increase Total Antioxidant Capacity in Critically Ill Patients.
International journal of molecular sciences2017The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
melatonin — increases total antioxidant capacity
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×2“After 4 h of the first melatonin administration (20:00), the serum of the melatonin patients was more protected against oxidant insults, displaying a significantly higher antioxidant capacity with respect to the placebo controls.”
Quoted verbatim from Melatonin Pharmacological Blood Levels Increase Total Antioxidant Capacity in Critically Ill Patients.. - Study
- RCT
- Dose
- 3 mg melatonin at 20:00 and 24:00 (6 mg per day) by enteral tube until ICU discharge
- Population
- Mechanically ventilated ICU patients with estimated ventilation over 8 days, enrolled from the 3rd ICU day; all patients received hospital-standard vitamin C, E and B group antioxidants. Measurement 4 h after the first dose, at 00:00 on the 4th ICU day
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