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Proteins/UNIPROT:Q92187
Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages. Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides, including NCAM1 N-glycans, FETUB N-glycans and AHSG. It is noteworthy that alpha-2,3-linked sialic acid is apparently a better acceptor than alpha-2,6-linked sialic acid..
Function from UniProtKB (Q92187), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
17 statements
17 statements · 5 reference databases · Subject: ST8SIA4 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
CMP-N-acetyl-beta-neuraminate+a ganglioside GM3 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD3 (d18:1(4E))+proton
Catalysed by ST8SIA4
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.-extracellular space
Human-GEM MAR12087CC BY 4.0Reference data
[N-acetyl-alpha-D-neuraminosyl-(2->8)](n)+CMP-N-acetyl-beta-neuraminate[N-acetyl-alpha-D-neuraminosyl-(2->8)](n+1)+CMP+hydron
Catalysed by
10 names
Resolves to: ST8SIA4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:77367CC BY 4.0Reference data