Proteins/UNIPROT:P13611

VCAN

ProteinUNIPROT:P13611

May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

Function from UniProtKB (P13611), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Wagner disease has a germline basis in VCANDiseaseGenCC HGNC:2464|MONDO:0007740Inferred only

Statements

77 statements

77 statements · 3 reference databases · Subject: VCAN · Sources: Hetionet, Reactome, WikiPathways

Order

VCAN covaries with ARMH4ProteinHetionet hetionet:covaries:145407-1462Inferred only
VCAN covaries with BRCA1ProteinHetionet hetionet:covaries:1462-672Inferred only
VCAN covaries with CMYA5ProteinHetionet hetionet:covaries:1462-202333Inferred only
VCAN covaries with KIAA2012ProteinHetionet hetionet:covaries:100652824-1462Inferred only
VCAN covaries with KLF17ProteinHetionet hetionet:covaries:128209-1462Inferred only
LRRC70 covaries with VCANProteinHetionet hetionet:covaries:100130733-1462Inferred only
VCAN covaries with MS4A7ProteinHetionet hetionet:covaries:1462-58475Inferred only
VCAN covaries with NCANProteinHetionet hetionet:covaries:1462-1463Inferred only
VCAN covaries with PCNX4ProteinHetionet hetionet:covaries:1462-64430Inferred only
PEX1 covaries with VCANProteinHetionet hetionet:covaries:1462-5189Inferred only
SPAG1 covaries with VCANProteinHetionet hetionet:covaries:1462-6674Inferred only
VCAN covaries with SYNE2ProteinHetionet hetionet:covaries:1462-23224Inferred only

Show the remaining 65

VCAN covaries with TRMT5ProteinHetionet hetionet:covaries:1462-57570Inferred only
VCAN covaries with ZFYVE16ProteinHetionet hetionet:covaries:1462-9765Inferred only
VCAN interacts with ADAMTS1ProteinHetionet hetionet:interacts:1462-9510Inferred only
VCAN interacts with CCL2ProteinHetionet hetionet:interacts:1462-6347Inferred only
VCAN interacts with CCL20ProteinHetionet hetionet:interacts:1462-6364Inferred only
VCAN interacts with CCL21ProteinHetionet hetionet:interacts:1462-6366Inferred only
VCAN interacts with CCL5ProteinHetionet hetionet:interacts:1462-6352Inferred only
VCAN interacts with CCL8ProteinHetionet hetionet:interacts:1462-6355Inferred only
CD44 interacts with VCANProteinHetionet hetionet:interacts:1462-960Inferred only
VCAN interacts with CXCL10ProteinHetionet hetionet:interacts:1462-3627Inferred only
VCAN interacts with FBLN1ProteinHetionet hetionet:interacts:1462-2192Inferred only
VCAN interacts with FBLN2ProteinHetionet hetionet:interacts:1462-2199Inferred only
HAPLN1 interacts with VCANProteinHetionet hetionet:interacts:1404-1462Inferred only
VCAN interacts with ITGA4ProteinHetionet hetionet:interacts:1462-3676Inferred only
VCAN interacts with PLA2G2AProteinHetionet hetionet:interacts:1462-5320Inferred only
VCAN interacts with SELPProteinHetionet hetionet:interacts:1462-6403Inferred only
VCAN interacts with TNRProteinHetionet hetionet:interacts:1462-7143Inferred only
VCAN interacts with XCL1ProteinHetionet hetionet:interacts:1462-6375Inferred only
VCAN participates in Chondroitin sulfate/dermatan sulfate metabolismPathwayReactome R-HSA-1793185Inferred only
VCAN participates in CS-GAG biosynthesisPathwayReactome R-HSA-2022870Inferred only
VCAN participates in CS/DS degradationPathwayReactome R-HSA-2024101Inferred only
VCAN participates in Defective B3GALT6 causes EDSP2 and SEMDJL1PathwayReactome R-HSA-4420332Inferred only
VCAN participates in Defective B3GAT3 causes JDSSDHDPathwayReactome R-HSA-3560801Inferred only
VCAN participates in Defective B4GALT7 causes EDS, progeroid typePathwayReactome R-HSA-3560783Inferred only
VCAN participates in Defective CHST14 causes EDS, musculocontractural typePathwayReactome R-HSA-3595174Inferred only
VCAN participates in Defective CHST3 causes SEDCJDPathwayReactome R-HSA-3595172Inferred only
VCAN participates in Defective CHSY1 causes TPBSPathwayReactome R-HSA-3595177Inferred only
VCAN participates in DiseasePathwayReactome R-HSA-1643685Inferred only
VCAN participates in Diseases associated with glycosaminoglycan metabolismPathwayReactome R-HSA-3560782Inferred only
VCAN participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
VCAN participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
VCAN participates in DS-GAG biosynthesisPathwayReactome R-HSA-2022923Inferred only
VCAN participates in ECM proteoglycansPathwayReactome R-HSA-3000178Inferred only
VCAN participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
VCAN participates in Glycosaminoglycan metabolismPathwayReactome R-HSA-1630316Inferred only
VCAN participates in Glycosaminoglycan-protein linkage region biosynthesisPathwayReactome R-HSA-1971475Inferred only
VCAN participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
VCAN participates in Metabolism of carbohydrates and carbohydrate derivativesPathwayReactome R-HSA-71387Inferred only
VCAN participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
VCAN participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
VCAN participates in Post-translational protein phosphorylationPathwayReactome R-HSA-8957275Inferred only
VCAN participates in Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)PathwayReactome R-HSA-381426Inferred only
VCAN participates in Spinal cord injuryPathwayWikiPathways WP2431Inferred only
VCAN increases the expression of ABCC5ProteinHetionet hetionet:regulates:1462-10057Inferred only
VCAN increases the expression of ADGRE1ProteinHetionet hetionet:regulates:1462-2015Inferred only
BCL7B decreases the expression of VCANProteinHetionet hetionet:regulates:9275-1462Inferred only
VCAN decreases the expression of CANT1ProteinHetionet hetionet:regulates:1462-124583Inferred only
VCAN decreases the expression of CASC3ProteinHetionet hetionet:regulates:1462-22794Inferred only
VCAN decreases the expression of CNN2ProteinHetionet hetionet:regulates:1462-1265Inferred only
VCAN decreases the expression of COASYProteinHetionet hetionet:regulates:1462-80347Inferred only
VCAN decreases the expression of FDFT1ProteinHetionet hetionet:regulates:1462-2222Inferred only
VCAN decreases the expression of FOXO4ProteinHetionet hetionet:regulates:1462-4303Inferred only
VCAN increases the expression of HERC6ProteinHetionet hetionet:regulates:1462-55008Inferred only
HPRT1 decreases the expression of VCANProteinHetionet hetionet:regulates:3251-1462Inferred only
VCAN decreases the expression of KDM3AProteinHetionet hetionet:regulates:1462-55818Inferred only
LRP10 increases the expression of VCANProteinHetionet hetionet:regulates:26020-1462Inferred only
VCAN decreases the expression of PAK4ProteinHetionet hetionet:regulates:1462-10298Inferred only
VCAN decreases the expression of PCNAProteinHetionet hetionet:regulates:1462-5111Inferred only
VCAN increases the expression of PHGDHProteinHetionet hetionet:regulates:1462-26227Inferred only
VCAN decreases the expression of PIK3R4ProteinHetionet hetionet:regulates:1462-30849Inferred only
VCAN decreases the expression of PTPN12ProteinHetionet hetionet:regulates:1462-5782Inferred only
VCAN decreases the expression of RALBProteinHetionet hetionet:regulates:1462-5899Inferred only
VCAN decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:1462-6192Inferred only
VCAN decreases the expression of SLC38A2ProteinHetionet hetionet:regulates:1462-54407Inferred only
VCAN increases the expression of TNFAIP3ProteinHetionet hetionet:regulates:1462-7128Inferred only

Other names

7 names

Resolves to: VCAN

Also called: Chondroitin sulfate proteoglycan 2Chondroitin sulfate proteoglycan core protein 2CSPG2GHAPGlial hyaluronate-binding proteinLarge fibroblast proteoglycanPG-M

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