Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P47992

XCL1

Protein·UNIPROT:P47992

Open in the graph

Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment..

Function from UniProtKB (P47992), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

41 statements

41 statements · 4 reference databases · Subject: XCL1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

VCAN interacts with XCL1ProteinHetionet hetionet:interacts:1462-6375Inferred only
XCR1 interacts with XCL1ProteinHetionet hetionet:interacts:2829-6375Inferred only
XCL1 participates in Chemokine receptors bind chemokinesPathwayReactome R-HSA-380108Inferred only
XCL1 participates in Chemokine signalingPathwayWikiPathways WP3929Inferred only
XCL1 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
XCL1 participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
XCL1 participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
XCL1 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
XCL1 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
XCL1 participates in Overview of proinflammatory and profibrotic mediatorsPathwayWikiPathways WP5095Inferred only
XCL1 participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
XCL1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only

Show the remaining 29

XCL1 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
XCL1 regulates negative regulation of CD4-positive, alpha-beta T cell proliferationBiological processgene ontology P47992|GO:2000562Inferred only
XCL1 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology P47992|GO:0045892Inferred only
XCL1 regulates negative regulation of interleukin-2 productionBiological processgene ontology P47992|GO:0032703Inferred only
XCL1 regulates negative regulation of T cell cytokine productionBiological processgene ontology P47992|GO:0002725Inferred only
XCL1 regulates negative regulation of T-helper 1 cell activationBiological processgene ontology P47992|GO:2000518Inferred only
XCL1 regulates negative regulation of T-helper 1 type immune responseBiological processgene ontology P47992|GO:0002826Inferred only
XCL1 regulates negative regulation of type II interferon productionBiological processgene ontology P47992|GO:0032689Inferred only
XCL1 regulates positive regulation of B cell chemotaxisBiological processgene ontology P47992|GO:2000538Inferred only
XCL1 regulates positive regulation of CD4-positive, alpha-beta T cell proliferationBiological processgene ontology P47992|GO:2000563Inferred only
XCL1 regulates positive regulation of CD8-positive, alpha-beta T cell proliferationBiological processgene ontology P47992|GO:2000566Inferred only
XCL1 regulates positive regulation of cell migrationBiological processgene ontology P47992|GO:0030335Inferred only
XCL1 regulates positive regulation of granzyme A productionBiological processgene ontology P47992|GO:2000513Inferred only
XCL1 regulates positive regulation of granzyme B productionBiological processgene ontology P47992|GO:0071663Inferred only
XCL1 regulates positive regulation of immunoglobulin production in mucosal tissueBiological processgene ontology P47992|GO:2000558Inferred only
XCL1 regulates positive regulation of interleukin-10 productionBiological processgene ontology P47992|GO:0032733Inferred only
XCL1 regulates positive regulation of leukocyte chemotaxisBiological processgene ontology P47992|GO:0002690Inferred only
XCL1 regulates positive regulation of natural killer cell chemotaxisBiological processgene ontology P47992|GO:2000503Inferred only
XCL1 regulates positive regulation of neutrophil chemotaxisBiological processgene ontology P47992|GO:0090023Inferred only
XCL1 regulates positive regulation of release of sequestered calcium ion into cytosolBiological processgene ontology P47992|GO:0051281Inferred only
XCL1 regulates positive regulation of T cell chemotaxisBiological processgene ontology P47992|GO:0010820Inferred only
XCL1 regulates positive regulation of T cell cytokine productionBiological processgene ontology P47992|GO:0002726Inferred only
XCL1 regulates positive regulation of T cell mediated cytotoxicityBiological processgene ontology P47992|GO:0001916Inferred only
XCL1 regulates positive regulation of T-helper 1 cell cytokine productionBiological processgene ontology P47992|GO:2000556Inferred only
XCL1 regulates positive regulation of T-helper 2 cell cytokine productionBiological processgene ontology P47992|GO:2000553Inferred only
XCL1 regulates positive regulation of thymocyte migrationBiological processgene ontology P47992|GO:2000412Inferred only
XCL1 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology P47992|GO:0045944Inferred only
XCL1 regulates positive regulation of transforming growth factor beta productionBiological processgene ontology P47992|GO:0071636Inferred only
XCL1 regulates regulation of inflammatory responseBiological processgene ontology P47992|GO:0050727Inferred only

Other names

9 names

Resolves to: XCL1

Also called: ATACC motif chemokine 1Cytokine SCM-1LTNLymphotaxinSCM-1-alphaSCYC1Small-inducible cytokine C1XC chemokine ligand 1

← Every protein Find it in the graph →