Proteins/UNIPROT:P80075

CCL8

ProteinUNIPROT:P80075

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8..

Function from UniProtKB (P80075), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 3 reference databases · Subject: CCL8 · Sources: gene ontology, Hetionet, WikiPathways

Order

CCL8 covaries with SLCO1B3ProteinHetionet hetionet:covaries:28234-6355Inferred only
ACKR1 interacts with CCL8ProteinHetionet hetionet:interacts:2532-6355Inferred only
ACKR2 interacts with CCL8ProteinHetionet hetionet:interacts:1238-6355Inferred only
CCL8 interacts with ACKR4ProteinHetionet hetionet:interacts:51554-6355Inferred only
CCL2 interacts with CCL8ProteinHetionet hetionet:interacts:6347-6355Inferred only
CCR1 interacts with CCL8ProteinHetionet hetionet:interacts:1230-6355Inferred only
CCL8 interacts with CCR2ProteinHetionet hetionet:interacts:6355-729230Inferred only
CCR3 interacts with CCL8ProteinHetionet hetionet:interacts:1232-6355Inferred only
CCR5 interacts with CCL8ProteinHetionet hetionet:interacts:1234-6355Inferred only
MMP3 interacts with CCL8ProteinHetionet hetionet:interacts:4314-6355Inferred only
VCAN interacts with CCL8ProteinHetionet hetionet:interacts:1462-6355Inferred only
CCL8 participates in 17q12 copy number variation syndromePathwayWikiPathways WP5287Inferred only

Show the remaining 7

CCL8 participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
CCL8 participates in Network map of SARS CoV 2 signalingPathwayWikiPathways WP5115Inferred only
CCL8 participates in Overview of proinflammatory and profibrotic mediatorsPathwayWikiPathways WP5095Inferred only
CCL8 participates in Uterine natural killer cells and progesterone estrogen and chorionic gonadotropinPathwayWikiPathways WP5569Inferred only
CCL8 regulates negative regulation of leukocyte proliferationBiological processgene ontology P80075|GO:0070664Inferred only
CCL8 regulates positive regulation of cell migrationBiological processgene ontology P80075|GO:0030335Inferred only
CCL8 regulates positive regulation of leukocyte migrationBiological processgene ontology P80075|GO:0002687Inferred only

Other names

10 names

Resolves to: CCL8

Also called: [Cleaved into: MCP-26-76HC14MCP-2MCP2Monocyte chemoattractant protein 2Monocyte chemotactic protein 2SCYA10SCYA8Small-inducible cytokine A8

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