SLCO1B3-SLCO1B7

Mediates the Na(+)-independent uptake of organic anions. Transports the conjugated steroids 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate) or E2G) and dehydroepiandrosterone 3-sulfate (DHEAS) at the smooth endoplasmic reticulum membrane (SER), granting access to metabolizing enzymes. Contributes to the metabolism of bile acids such as taurocholate (cholyltaurine) and lithocholate, by functioning as a doorway between SER and cytosol, thereby decreasing their circulating levels and protecting the organism from their detergent properties. Regulates access or exit of drugs to the SER lumen..

Function from UniProtKB (F5H094), read 2026-09-23. CC BY 4.0.